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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone Experiences
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<blockquote data-quote="Gus80" data-source="post: 247018" data-attributes="member: 45069"><p>In rats nandrolone decreases serotonin. Something that could be good for men with a tendency to schizophrenia or bipolarity, who experience high levels of serotonin/dopamine. It's my case, T makes me anxious, hypomanic and with sexual compulsion (high e2 increases serotonin which prevents sexual satiety). Deca Only made me feel like a Buddhist Zen master, and in 3 months I was practically celibate due to zero libido, lol.</p><p></p><p>As for those who have low serotonin / dopamine, tendency to depression, testosterone would be better.</p><p></p><p>I hypothesize that they are genetic issues, those already discovered and common in society are the mutations of the MAOa and Comt genes, which can be slow or fast, and regulate the excretion speed of dopamine, serotonin and estrogen. In addition to MTHFR which impairs methylation in general, impairing the excretion of toxins, as well as leaving too much unmethylated estrogen in the body. According to Dr Ben Lynch, methylated estrogen is beneficial, unmethylated estrogen is what causes the known estrogen dominance problems.</p><p></p><p>Extrapolating this data to my practical experience:</p><p>- slow comt, slow maoa and mthfr: tend to have more difficulty with testosterone and with high doses infrequently. They tend to get a lot of anxiety on traditional trt or cycling protocols as they build up dopamine, serotonin and estrogen. They tend to have low shbg, metabolic syndrome, fatty liver and high homocysteine, in these TRT will worsen insulin resistance by further decreasing shbg. They are the best candidates for Deca Only or Deca Base and microdoses of T. Or rather, ideally they are the perfect candidates for clomid, which would help them increase shbg and slim down and come out of hypogonadism. Keto diet, Carnivore Diet, Low Carb, Atkins, etc. They are also generally slow metabolizers of caffeine and benefit from B Complex Vitamins (which improve methylation, especially b2, b6, b9 and b12) and calming agents such as phosphatidylserine, theanine, niacin, taurine, which reduce high cortisol/glutamate/dopamine /serotonin generated by TRT.</p><p></p><p>- Fast Comt and Fast Maoa: Fast metabolizers, tend to have low dopamine, serotonin and estrogen. I believe they are the majority among bodybuilders, who support very high doses of several hormones combined, with few side effects. They have high sensitivity to insulin, which allows them to eat loads of carbohydrates, something potentiated by T. They feel the beneficial effects of TRT immediately but tend to have depression because they metabolize too quickly.</p><p></p><p>And in the middle there are those who do not have these mutations. Many of them will not have hypogonadism, even in old age.</p></blockquote><p></p>
[QUOTE="Gus80, post: 247018, member: 45069"] In rats nandrolone decreases serotonin. Something that could be good for men with a tendency to schizophrenia or bipolarity, who experience high levels of serotonin/dopamine. It's my case, T makes me anxious, hypomanic and with sexual compulsion (high e2 increases serotonin which prevents sexual satiety). Deca Only made me feel like a Buddhist Zen master, and in 3 months I was practically celibate due to zero libido, lol. As for those who have low serotonin / dopamine, tendency to depression, testosterone would be better. I hypothesize that they are genetic issues, those already discovered and common in society are the mutations of the MAOa and Comt genes, which can be slow or fast, and regulate the excretion speed of dopamine, serotonin and estrogen. In addition to MTHFR which impairs methylation in general, impairing the excretion of toxins, as well as leaving too much unmethylated estrogen in the body. According to Dr Ben Lynch, methylated estrogen is beneficial, unmethylated estrogen is what causes the known estrogen dominance problems. Extrapolating this data to my practical experience: - slow comt, slow maoa and mthfr: tend to have more difficulty with testosterone and with high doses infrequently. They tend to get a lot of anxiety on traditional trt or cycling protocols as they build up dopamine, serotonin and estrogen. They tend to have low shbg, metabolic syndrome, fatty liver and high homocysteine, in these TRT will worsen insulin resistance by further decreasing shbg. They are the best candidates for Deca Only or Deca Base and microdoses of T. Or rather, ideally they are the perfect candidates for clomid, which would help them increase shbg and slim down and come out of hypogonadism. Keto diet, Carnivore Diet, Low Carb, Atkins, etc. They are also generally slow metabolizers of caffeine and benefit from B Complex Vitamins (which improve methylation, especially b2, b6, b9 and b12) and calming agents such as phosphatidylserine, theanine, niacin, taurine, which reduce high cortisol/glutamate/dopamine /serotonin generated by TRT. - Fast Comt and Fast Maoa: Fast metabolizers, tend to have low dopamine, serotonin and estrogen. I believe they are the majority among bodybuilders, who support very high doses of several hormones combined, with few side effects. They have high sensitivity to insulin, which allows them to eat loads of carbohydrates, something potentiated by T. They feel the beneficial effects of TRT immediately but tend to have depression because they metabolize too quickly. And in the middle there are those who do not have these mutations. Many of them will not have hypogonadism, even in old age. [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone Experiences
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