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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone Experiences
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<blockquote data-quote="DS3" data-source="post: 214053" data-attributes="member: 18514"><p>Much of the research suggests a direct impact of the nandrolone hormone on the central nervous system. There is no research directly linking it to depression, however. This is not to suggest that it does not create depression in some men, simply that there has been a lack of inquiry from researchers.</p><p></p><p>Testosterone and it’s derivatives, including nandrolone, have a direct impact on the central nervous system independent of its metabolites (e.g., DHT and estrogen, or DHN in the case of nandrolone). As testosterone or its derivatives cross the blood-brain barrier, they can directly impact neurotransmitter levels including but not limited to GABA, glutamate, dopamine, serotonin, and acetylcholine. The changing level of these neurotransmitters may alter mood, energy, and even personality. </p><p></p><p>Nandrolone’s impact on depression is more likely attributed to its direct effects in the CNS once it crosses the blood-brain barrier by altering various levels of neurotransmitters, including dopamine. </p><p></p><p>It is very unlikely that nandrolone’s potential for creating depressive states in some men has anything to do with DHN, nor the sensitizing of estrogen or progesterone receptors. If this plays any role, it is likely minimal. </p><p></p><p>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462037/[/URL]</p></blockquote><p></p>
[QUOTE="DS3, post: 214053, member: 18514"] Much of the research suggests a direct impact of the nandrolone hormone on the central nervous system. There is no research directly linking it to depression, however. This is not to suggest that it does not create depression in some men, simply that there has been a lack of inquiry from researchers. Testosterone and it’s derivatives, including nandrolone, have a direct impact on the central nervous system independent of its metabolites (e.g., DHT and estrogen, or DHN in the case of nandrolone). As testosterone or its derivatives cross the blood-brain barrier, they can directly impact neurotransmitter levels including but not limited to GABA, glutamate, dopamine, serotonin, and acetylcholine. The changing level of these neurotransmitters may alter mood, energy, and even personality. Nandrolone’s impact on depression is more likely attributed to its direct effects in the CNS once it crosses the blood-brain barrier by altering various levels of neurotransmitters, including dopamine. It is very unlikely that nandrolone’s potential for creating depressive states in some men has anything to do with DHN, nor the sensitizing of estrogen or progesterone receptors. If this plays any role, it is likely minimal. [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462037/[/URL] [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone Experiences
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