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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone Experiences
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<blockquote data-quote="JA Battle" data-source="post: 194640" data-attributes="member: 40068"><p>Yes, limiting aromatization is neurotoxic. </p><p> </p><p>As far as I’m concerned, nandrolone is not directly neurotoxic. It is it’s affinity for the androgen receptor and activating it without also concurrently being able to aromatize and balance out the metabolic effects with adequate estrogen receptor activation.</p><p></p><p>And yes a sufficient amount of estradiol is needed however with more androgen load, be it from any source (test, dht , nandrolone) a matching activation of the estrogen receptor is needed. This is why with higher testosterone a concurrently higher estradiol is needed for most men to feel and function properly.</p><p></p><p>If proper balance between estrogen and androgen receptor activation can be achieved it really doesn’t matter the hormone as long as the hormone is not super selective as far as receptor subtype. This is why I believe oxandrolone to not be found neurotoxic. It is a more selective drug as far as androgen receptor activation. </p><p></p><p> In many cases using nandrolone as a base won’t be sustainable because of these reasons. Unless of course someone aromatizes a lot from some added testosterone Or uses enough hcg to create enough e2 or supplements e2 directly. Nandrolone must be balanced with e2 from some source to be viable and not neurotoxic.</p></blockquote><p></p>
[QUOTE="JA Battle, post: 194640, member: 40068"] Yes, limiting aromatization is neurotoxic. As far as I’m concerned, nandrolone is not directly neurotoxic. It is it’s affinity for the androgen receptor and activating it without also concurrently being able to aromatize and balance out the metabolic effects with adequate estrogen receptor activation. And yes a sufficient amount of estradiol is needed however with more androgen load, be it from any source (test, dht , nandrolone) a matching activation of the estrogen receptor is needed. This is why with higher testosterone a concurrently higher estradiol is needed for most men to feel and function properly. If proper balance between estrogen and androgen receptor activation can be achieved it really doesn’t matter the hormone as long as the hormone is not super selective as far as receptor subtype. This is why I believe oxandrolone to not be found neurotoxic. It is a more selective drug as far as androgen receptor activation. In many cases using nandrolone as a base won’t be sustainable because of these reasons. Unless of course someone aromatizes a lot from some added testosterone Or uses enough hcg to create enough e2 or supplements e2 directly. Nandrolone must be balanced with e2 from some source to be viable and not neurotoxic. [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone Experiences
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