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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone Experiences
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<blockquote data-quote="madman" data-source="post: 182689" data-attributes="member: 13851"><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/estradiol-is-an-important-hormone-for-men.19048/#post-152259[/URL]</p><p></p><p></p><p></p><p><strong>Growth hormone-insulin-like growth factor-1 axis</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong><span style="color: rgb(184, 49, 47)">Men with congenital aromatase deficiency have impaired stimulated growth hormone (GH) secretion and low insulin-like growth factor-1 (IGF-1) (<a href="https://eje.bioscientifica.com/view/journals/eje/181/1/EJE-18-1000.xml#bib66" target="_blank">66</a>).</span></strong> Exogenous E2 in these men was not able to normalize GH secretion (<a href="https://eje.bioscientifica.com/view/journals/eje/181/1/EJE-18-1000.xml#bib66" target="_blank">66</a>), possibly because of abnormal development of the GH–IGF-1 axis in the setting of congenital E2 deficiency or because restoration of normal circulating E2 concentration is insufficient if local E2 production remains impaired (<a href="https://eje.bioscientifica.com/view/journals/eje/181/1/EJE-18-1000.xml#bib67" target="_blank">67</a>).<strong> <span style="color: rgb(184, 49, 47)">Additional lines of evidence from preclinical models, women, and indirect evidence from men, suggest that E2 is important in regulation of GH secretion by both direct and indirect mechanisms (<a href="https://eje.bioscientifica.com/view/journals/eje/181/1/EJE-18-1000.xml#bib67" target="_blank">67</a>, <a href="https://eje.bioscientifica.com/view/journals/eje/181/1/EJE-18-1000.xml#bib68" target="_blank">68</a>).</span></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong><span style="color: rgb(44, 130, 201)">*In summary,</span><span style="color: rgb(184, 49, 47)"><u> E2 rather than testosterone</u></span><span style="color: rgb(44, 130, 201)"> appears the main sex steroid regulator of the GH-IGF-1 axis in men.</span></strong></p></blockquote><p></p>
[QUOTE="madman, post: 182689, member: 13851"] [URL unfurl="true"]https://www.excelmale.com/forum/threads/estradiol-is-an-important-hormone-for-men.19048/#post-152259[/URL] [B]Growth hormone-insulin-like growth factor-1 axis [COLOR=rgb(184, 49, 47)]Men with congenital aromatase deficiency have impaired stimulated growth hormone (GH) secretion and low insulin-like growth factor-1 (IGF-1) ([URL='https://eje.bioscientifica.com/view/journals/eje/181/1/EJE-18-1000.xml#bib66']66[/URL]).[/COLOR][/B][COLOR=rgb(184, 49, 47)] [/COLOR]Exogenous E2 in these men was not able to normalize GH secretion ([URL='https://eje.bioscientifica.com/view/journals/eje/181/1/EJE-18-1000.xml#bib66']66[/URL]), possibly because of abnormal development of the GH–IGF-1 axis in the setting of congenital E2 deficiency or because restoration of normal circulating E2 concentration is insufficient if local E2 production remains impaired ([URL='https://eje.bioscientifica.com/view/journals/eje/181/1/EJE-18-1000.xml#bib67']67[/URL]).[B] [COLOR=rgb(184, 49, 47)]Additional lines of evidence from preclinical models, women, and indirect evidence from men, suggest that E2 is important in regulation of GH secretion by both direct and indirect mechanisms ([URL='https://eje.bioscientifica.com/view/journals/eje/181/1/EJE-18-1000.xml#bib67']67[/URL], [URL='https://eje.bioscientifica.com/view/journals/eje/181/1/EJE-18-1000.xml#bib68']68[/URL]).[/COLOR] [COLOR=rgb(44, 130, 201)]*In summary,[/COLOR][COLOR=rgb(184, 49, 47)][U] E2 rather than testosterone[/U][/COLOR][COLOR=rgb(44, 130, 201)] appears the main sex steroid regulator of the GH-IGF-1 axis in men.[/COLOR][/B][COLOR=rgb(44, 130, 201)] [/COLOR] [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone Experiences
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