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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone Experiences
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<blockquote data-quote="DS3" data-source="post: 175439" data-attributes="member: 18514"><p><span style="color: rgb(44, 130, 201)">"DHT’s hardening effect comes from Test being reduced at the skin level which thins the skin / less subQ fat." </span><span style="color: rgb(0, 0, 0)">This assertion is probably partially correct. The study below discusses similar results in men who were administered transdermal DHT for 90 days and the results demonstrate a reduction in skinfold thickness and fat mass. DHT's inactivation within muscle tissue via the 3a-hydroxysteroid dehydrogenase enzyme was already established. I wasn't proposing an explanation for the masculizing/hardening effects of DHT that pertained to its activity or inactivity in muscle tissue. </span></p><p></p><p>Study 1: <a href="https://academic.oup.com/jcem/article/86/9/4078/2848414" target="_blank">Double-Blind, Placebo-Controlled, Randomized Clinical Trial of Transdermal Dihydrotestosterone Gel on Muscular Strength, Mobility, and Quality of Life in Older Men with Partial Androgen Deficiency</a></p><p>Study 2: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167122/" target="_blank">Dihydrotestosterone stimulates amino acid uptake and the expression of LAT2 in mouse skeletal muscle fibres through an ERK1/2-dependent mechanism</a></p><p></p><p>However, in the second study, the results indicate that DHT may actually play an essential role in protein synthesis and the subsequent transport of essential amino acids into fast-twitch muscle fibers. Interesting results. Perhaps DHT doesn't play an inconsequential role in muscle fiber.</p><p></p><p>Study 3: <a href="https://www.ncbi.nlm.nih.gov/pubmed/6645492" target="_blank">Evaluation of androgen antagonism of estrogen effect by dihydrotestosterone. - PubMed - NCBI</a></p><p></p><p>DHT also has antagonistic effects within various organs. The posted study discusses the antagonistic effect of DHT in the uterus, which serves as a simple example of estrogen antagonism. I have yet to be able to find evidence as to whether DHT has an anti-estrogenic role in muscle tissue, although I intuitively believe this would be true (with as little of value as belief without proof provides).</p></blockquote><p></p>
[QUOTE="DS3, post: 175439, member: 18514"] [COLOR=rgb(44, 130, 201)]"DHT’s hardening effect comes from Test being reduced at the skin level which thins the skin / less subQ fat." [/COLOR][COLOR=rgb(0, 0, 0)]This assertion is probably partially correct. The study below discusses similar results in men who were administered transdermal DHT for 90 days and the results demonstrate a reduction in skinfold thickness and fat mass. DHT's inactivation within muscle tissue via the 3a-hydroxysteroid dehydrogenase enzyme was already established. I wasn't proposing an explanation for the masculizing/hardening effects of DHT that pertained to its activity or inactivity in muscle tissue. [/COLOR] Study 1: [URL='https://academic.oup.com/jcem/article/86/9/4078/2848414']Double-Blind, Placebo-Controlled, Randomized Clinical Trial of Transdermal Dihydrotestosterone Gel on Muscular Strength, Mobility, and Quality of Life in Older Men with Partial Androgen Deficiency[/URL] Study 2: [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167122/']Dihydrotestosterone stimulates amino acid uptake and the expression of LAT2 in mouse skeletal muscle fibres through an ERK1/2-dependent mechanism[/URL] However, in the second study, the results indicate that DHT may actually play an essential role in protein synthesis and the subsequent transport of essential amino acids into fast-twitch muscle fibers. Interesting results. Perhaps DHT doesn't play an inconsequential role in muscle fiber. Study 3: [URL="https://www.ncbi.nlm.nih.gov/pubmed/6645492"]Evaluation of androgen antagonism of estrogen effect by dihydrotestosterone. - PubMed - NCBI[/URL] DHT also has antagonistic effects within various organs. The posted study discusses the antagonistic effect of DHT in the uterus, which serves as a simple example of estrogen antagonism. I have yet to be able to find evidence as to whether DHT has an anti-estrogenic role in muscle tissue, although I intuitively believe this would be true (with as little of value as belief without proof provides). [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone Experiences
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