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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone Experiences
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<blockquote data-quote="DS3" data-source="post: 170903" data-attributes="member: 18514"><p>"Why are you so certain that your subjective results are not the product of the different release rates of testosterone by the different esters?"</p><p></p><p>I am not certain of this. My standpoint has been that subjective and objective differences appear to exist in how I respond to Cyp/Enanthate versus Propionate. The side effects that I experience are quantifiable simply by referring to my scale rating I keep on a daily basis for the past few years. I track this every day so I can literally look back at this data and gain an average for any protocol I have run over the last 3 years.</p><p></p><p>[ATTACH=full]9187[/ATTACH]</p><p></p><p>In terms of blood assays, perhaps my TT does indeed spike to 1800 ng/dL after a 75 mg shot of Prop and by the time I test it at 10 hours post shot it's at 1178 ng/dL (verified). So, it is possible that I may have mistaken the amount of TT I get from Propionate versus a lower dosage of Cyp/Enan. Perhaps the symptom relief from taking Propionate versus Cyp/Enan doesn't have anything to do with an inherent flaw with the way my body metabolizes long esters. Rather, perhaps it is the release rates of longer esters that create the aforementioned side effects that I do not experience with Propionate. I am not saying that this in indeed true, but it may be.</p><p></p><p>If this were true, that does not detract from the fact that <strong>this serves as a message </strong>that a patient on TRT may indeed experience varying side effects using longer or shorter esters- perhaps based on release rates of testosterone by different esters. These side effects leading to varying rates in therapeutic success among TRT patients.</p><p></p><p><strong>Pharmacokinetics of cypionate and enanthate</strong></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5182226/" target="_blank">Pharmacology of testosterone replacement therapy preparations</a></p><p></p><p><strong>Pharmacokinetics of propionate</strong></p><p><a href="https://www.researchgate.net/figure/Multiple-dose-pharmacokinetics-of-testosterone-propionate-after-injection-of-50-mg_fig4_264848721" target="_blank">Fig. 14.5 Multiple-dose pharmacokinetics of testosterone propionate...</a></p><p></p><p><strong>Pharmacokinetics of cypionate and enanthate </strong></p><p><a href="https://www.researchgate.net/figure/Comparative-pharmacokinetics-of-194-mg-of-testosterone-enanthate-and-200-mg-of_fig7_264848721" target="_blank">Fig. 14.8 Comparative pharmacokinetics of 194 mg of testosterone...</a></p><p></p><p><strong>Pharmacokinetic profile comparison of Testoviron Depot, Test Enanthate, and Test Propionate</strong></p><p><a href="https://www.researchgate.net/figure/Pharmacokinetic-profile-of-Testoviron-R-Depot-100-110-mg-testosterone-enanthate-and-25_fig8_264848721" target="_blank">Fig. 14.9 Pharmacokinetic profile of Testoviron R Depot 100 (110 mg...</a></p></blockquote><p></p>
[QUOTE="DS3, post: 170903, member: 18514"] "Why are you so certain that your subjective results are not the product of the different release rates of testosterone by the different esters?" I am not certain of this. My standpoint has been that subjective and objective differences appear to exist in how I respond to Cyp/Enanthate versus Propionate. The side effects that I experience are quantifiable simply by referring to my scale rating I keep on a daily basis for the past few years. I track this every day so I can literally look back at this data and gain an average for any protocol I have run over the last 3 years. [ATTACH=full]9187[/ATTACH] In terms of blood assays, perhaps my TT does indeed spike to 1800 ng/dL after a 75 mg shot of Prop and by the time I test it at 10 hours post shot it's at 1178 ng/dL (verified). So, it is possible that I may have mistaken the amount of TT I get from Propionate versus a lower dosage of Cyp/Enan. Perhaps the symptom relief from taking Propionate versus Cyp/Enan doesn't have anything to do with an inherent flaw with the way my body metabolizes long esters. Rather, perhaps it is the release rates of longer esters that create the aforementioned side effects that I do not experience with Propionate. I am not saying that this in indeed true, but it may be. If this were true, that does not detract from the fact that [B]this serves as a message [/B]that a patient on TRT may indeed experience varying side effects using longer or shorter esters- perhaps based on release rates of testosterone by different esters. These side effects leading to varying rates in therapeutic success among TRT patients. [B]Pharmacokinetics of cypionate and enanthate[/B] [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5182226/']Pharmacology of testosterone replacement therapy preparations[/URL] [B]Pharmacokinetics of propionate[/B] [URL='https://www.researchgate.net/figure/Multiple-dose-pharmacokinetics-of-testosterone-propionate-after-injection-of-50-mg_fig4_264848721']Fig. 14.5 Multiple-dose pharmacokinetics of testosterone propionate...[/URL] [B]Pharmacokinetics of cypionate and enanthate [/B] [URL='https://www.researchgate.net/figure/Comparative-pharmacokinetics-of-194-mg-of-testosterone-enanthate-and-200-mg-of_fig7_264848721']Fig. 14.8 Comparative pharmacokinetics of 194 mg of testosterone...[/URL] [B]Pharmacokinetic profile comparison of Testoviron Depot, Test Enanthate, and Test Propionate[/B] [URL='https://www.researchgate.net/figure/Pharmacokinetic-profile-of-Testoviron-R-Depot-100-110-mg-testosterone-enanthate-and-25_fig8_264848721']Fig. 14.9 Pharmacokinetic profile of Testoviron R Depot 100 (110 mg...[/URL] [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone Experiences
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