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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone Experiences
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<blockquote data-quote="Jason Sypolt" data-source="post: 170773" data-attributes="member: 13328"><p>I am not aware of any evidence, or that it is known, and I doubt that this information is something that would justify the cost in obtaining it.</p><p></p><p>From a purely logical standpoint though, you would really have to conclude that there have to be substantial differences between endogenous and exogenous. It is a sort of truth problem. Either it is all exactly the same, or none of it is and thus there is a difference somewhere.</p><ul> <li data-xf-list-type="ul">It is not brought into the body by the same method or in the same place.</li> <li data-xf-list-type="ul">It has to travel through different tissue, largely because of the first point.</li> <li data-xf-list-type="ul">Although "bioidentical", that is simply the molecule. There are preservatives and esters and those are not identical to anything in the body, nor do they release androgens at the same rate.</li> </ul><p>And then anecdotally, I have seen very few people who do well on an equivalent of 7-10mg per day even accounting for the weight of the ester. Although there are far more men than not who are mostly looking at T for the problems and not much (or anything) else.</p><p></p><p>As far as safety, higher-dose androgens have been regularly given to people with HIV since the 90's, so there must be some data on medium-term use relative to safety. Prescribing responsibly goes a long way as well. Tracking symptoms, requiring more and more frequent labs, and staying in communication. There some maybe borderline conspiracy theories that we are being intentionally feminized and that even our grandparents had far higher hormone levels, does that make higher androgens safe? Maybe, but then again maybe not. All of the information that would have been needed to determine that was lost to time.</p><p></p><p>Personally (and this is a personal decision for everyone), I would rather take this stuff even if it meant a shorter life (which it doesn't, according to most current data) in order to have a better life.</p><p></p><p>I no longer have 400+ triglycerides, throw out my back moving a chair and have to shuffle my feel like an old man for a week in excruciating pain, no interest in anything, and a circulating insulin level that is 6 times what a safe amount should be - all while accepting that as normal. I look better, feel better, and I can operate at a high level through my insanely busy work day which has not only been rewarding to me, but it changes others' lives as well. I will choose that any day.</p></blockquote><p></p>
[QUOTE="Jason Sypolt, post: 170773, member: 13328"] I am not aware of any evidence, or that it is known, and I doubt that this information is something that would justify the cost in obtaining it. From a purely logical standpoint though, you would really have to conclude that there have to be substantial differences between endogenous and exogenous. It is a sort of truth problem. Either it is all exactly the same, or none of it is and thus there is a difference somewhere. [LIST] [*]It is not brought into the body by the same method or in the same place. [*]It has to travel through different tissue, largely because of the first point. [*]Although "bioidentical", that is simply the molecule. There are preservatives and esters and those are not identical to anything in the body, nor do they release androgens at the same rate. [/LIST] And then anecdotally, I have seen very few people who do well on an equivalent of 7-10mg per day even accounting for the weight of the ester. Although there are far more men than not who are mostly looking at T for the problems and not much (or anything) else. As far as safety, higher-dose androgens have been regularly given to people with HIV since the 90's, so there must be some data on medium-term use relative to safety. Prescribing responsibly goes a long way as well. Tracking symptoms, requiring more and more frequent labs, and staying in communication. There some maybe borderline conspiracy theories that we are being intentionally feminized and that even our grandparents had far higher hormone levels, does that make higher androgens safe? Maybe, but then again maybe not. All of the information that would have been needed to determine that was lost to time. Personally (and this is a personal decision for everyone), I would rather take this stuff even if it meant a shorter life (which it doesn't, according to most current data) in order to have a better life. I no longer have 400+ triglycerides, throw out my back moving a chair and have to shuffle my feel like an old man for a week in excruciating pain, no interest in anything, and a circulating insulin level that is 6 times what a safe amount should be - all while accepting that as normal. I look better, feel better, and I can operate at a high level through my insanely busy work day which has not only been rewarding to me, but it changes others' lives as well. I will choose that any day. [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone Experiences
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