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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone Experiences
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<blockquote data-quote="DS3" data-source="post: 169969" data-attributes="member: 18514"><p>[USER=15043]@Gman86[/USER] [USER=39049]@Rock H. Johnson[/USER]</p><p></p><p>Study conducted by Larry Lipschultz et al., at the Baylor College of Medicine regarding nandrolone and joint pain relief in hypogonadal men. (I know most guys on this forum have seen this novel study).</p><p></p><p><strong>ERECTILE DYSFUNCTION:</strong> Regarding erectile dysfunction, the study posited this note, "Interestingly, although not well described in the literature, some users of nandrolone have complained of temporary ED that resolves with cessation of therapy (13). This anecdotal side effect <strong>appears to be highly dependent on nandrolone dosage and the use or absence of concomitant testosterone.</strong> Although further studies regarding this are needed, plausible mechanisms for this include the <strong>insufficient androgenic activity of nandrolone itself</strong> and negative-feedback induced suppression of the HPG axis resulting in both <strong>reduced testosterone and DHT, the latter of which crucial to nitric-oxide mediated erectile function </strong>(13,29). </p><p></p><p>From this sentiment, Lipshultz and his colleagues appear to be saying that as DHN and DHT are competing for the androgen receptor, if too much DHN binds to the AR in relation to DHT, then ED could be experienced by men due to DHT's role in nitric-oxide mediated erectile function, and DHN's lack thereof.</p><p></p><p>Below is the study that Lipschultz et al. site regarding DHT's role in nitric-oxide mediated erectile function.</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/7534702" target="_blank">Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat. - PubMed - NCBI</a></p><p></p><p>From this evidence, though not conclusive as more studies would need to be done, this evidence does provide some rationale for using a DHT-derived anabolic such as <strong>Proviron</strong> or <strong>Masteron</strong> during nandrolone therapy as a means of keeping DHT elevated. However, given that while using nandrolone with testosterone, patients will see a reduction in baseline (from testosterone monotherapy E2 and prolactin levels) prolactin and estrogen, adding Proviron or Masteron to the mix could further drive down E2, adding low E2 symptoms to the mix, which is problematic.</p></blockquote><p></p>
[QUOTE="DS3, post: 169969, member: 18514"] [USER=15043]@Gman86[/USER] [USER=39049]@Rock H. Johnson[/USER] Study conducted by Larry Lipschultz et al., at the Baylor College of Medicine regarding nandrolone and joint pain relief in hypogonadal men. (I know most guys on this forum have seen this novel study). [B]ERECTILE DYSFUNCTION:[/B] Regarding erectile dysfunction, the study posited this note, "Interestingly, although not well described in the literature, some users of nandrolone have complained of temporary ED that resolves with cessation of therapy (13). This anecdotal side effect [B]appears to be highly dependent on nandrolone dosage and the use or absence of concomitant testosterone.[/B] Although further studies regarding this are needed, plausible mechanisms for this include the [B]insufficient androgenic activity of nandrolone itself[/B] and negative-feedback induced suppression of the HPG axis resulting in both [B]reduced testosterone and DHT, the latter of which crucial to nitric-oxide mediated erectile function [/B](13,29). From this sentiment, Lipshultz and his colleagues appear to be saying that as DHN and DHT are competing for the androgen receptor, if too much DHN binds to the AR in relation to DHT, then ED could be experienced by men due to DHT's role in nitric-oxide mediated erectile function, and DHN's lack thereof. Below is the study that Lipschultz et al. site regarding DHT's role in nitric-oxide mediated erectile function. [URL='https://www.ncbi.nlm.nih.gov/pubmed/7534702']Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat. - PubMed - NCBI[/URL] From this evidence, though not conclusive as more studies would need to be done, this evidence does provide some rationale for using a DHT-derived anabolic such as [B]Proviron[/B] or [B]Masteron[/B] during nandrolone therapy as a means of keeping DHT elevated. However, given that while using nandrolone with testosterone, patients will see a reduction in baseline (from testosterone monotherapy E2 and prolactin levels) prolactin and estrogen, adding Proviron or Masteron to the mix could further drive down E2, adding low E2 symptoms to the mix, which is problematic. [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone Experiences
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