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I only got achy knuckles after my 80 days test with Proviron. Achy joints, knuckles and being slightly emotional are my feedback signals to lower my Masteron dose as it indicates lowered E2 for me too. I also use DHEA to up the E2. Libido has never been an issue. I have not started the Nandrolone yet, but will start soon with 2:1.(so cannot comment based on personal experience)