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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone Experiences
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<blockquote data-quote="Cataceous" data-source="post: 168158" data-attributes="member: 38109"><p>A couple things: Nandrolone may have a stronger binding affinity for the androgen receptor (double?) than testosterone. Beyond that, I suspect nandrolone and testosterone do similar things once bound to the androgen receptor. But in addition, nandrolone is converted to DHN instead of DHT, and DHN is much less androgenic. So you get a lot of anabolic activity relative to androgenic. <em>"The conversion of testosterone into DHT is an important factor in the etiology of a variety of androgen-dependent conditions, including acne, excessive facial/body hair growth, scalp hair loss, prostate enlargement, and prostate cancer. Unlike the case of testosterone and DHT, 5α-DHN is a much weaker agonist of the androgen receptor (AR) than is nandrolone. For this reason, <strong>instead of local potentiation in androgenic tissues, there is a local inactivation</strong> when nandrolone is converted into 5α-DHN by 5α-reductase in these tissues."[</em><a href="https://en.wikipedia.org/wiki/5α-Dihydronandrolone" target="_blank"><em>1</em></a><em>]</em></p></blockquote><p></p>
[QUOTE="Cataceous, post: 168158, member: 38109"] A couple things: Nandrolone may have a stronger binding affinity for the androgen receptor (double?) than testosterone. Beyond that, I suspect nandrolone and testosterone do similar things once bound to the androgen receptor. But in addition, nandrolone is converted to DHN instead of DHT, and DHN is much less androgenic. So you get a lot of anabolic activity relative to androgenic. [I]"The conversion of testosterone into DHT is an important factor in the etiology of a variety of androgen-dependent conditions, including acne, excessive facial/body hair growth, scalp hair loss, prostate enlargement, and prostate cancer. Unlike the case of testosterone and DHT, 5α-DHN is a much weaker agonist of the androgen receptor (AR) than is nandrolone. For this reason, [B]instead of local potentiation in androgenic tissues, there is a local inactivation[/B] when nandrolone is converted into 5α-DHN by 5α-reductase in these tissues."[[/I][URL='https://en.wikipedia.org/wiki/5α-Dihydronandrolone'][I]1[/I][/URL][I]][/I] [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Nandrolone Experiences
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