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Nutrition and Supplements
NAD, Hype Or Miracle Molecule?
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<blockquote data-quote="jmzwy" data-source="post: 152852" data-attributes="member: 24750"><p>Chiming in here a few months after the fact. I tried Tru Niagen NR 250 mg. May have already been said here, but apparently NR is currently the most effective NAD precursor to 'get inside' the cells and increase NAD+. Anyway I began taking the supplement, with absolutely no other changes in my diet/supplements/exercise/etc, and within 3 days I experienced the worst somnolence and fatigue of my entire life. Literally was sleeping 9 hours a night (I'm usually 7-8), and taking multiple naps during the day. I discontinued the supplement and the side effects disappeared within 36 hours. I gave the supplement the benefit of the doubt, and was open to the fact that perhaps I had caught some bug. Anyway, I started the supplement again about a week later and the exact same thing happened after just 2 days. Wanting to 'snap myself out of it' I took a mountain bike ride - literally the worst ride and likely the most dangerous I've been on, even though the trail was simple (not too steep and not technical); I had almost no energy and no focus. I stopped taking the supplement and of course within 24 hours I'm fine. There was a study showing mice that had their NAD+ levels boosted with NR had decreased exercise performance.... and it wasn't marginal. It was an average 35% less than the control group. And only one mouse on the NAD+ managed to surpass the median level of the control group. Wondering if this stuff, while showing anti-aging 'benefits,' comes at the price of basically shutting down the energy delivery systems (at least for people like me). Kind of like cryo-freeze or cryo-sleep in the movies. Again we are not rats and this is just my experience. I desperately wanted this stuff to work; I would have been fine and kept going on it even if I felt nothing, with the assumption that the benefits were taking place under the surface. Anyway there ya have it and here is the mouse/rat study: <a href="https://jissn.biomedcentral.com/articles/10.1186/s12970-016-0143-x" target="_blank">The NAD + precursor nicotinamide riboside decreases exercise performance in rats</a> and <a href="https://blog.priceplow.com/supplement-news/niagen-decreases-performance" target="_blank">Niagen Research Shows DECREASED Athletic Performance!</a></p></blockquote><p></p>
[QUOTE="jmzwy, post: 152852, member: 24750"] Chiming in here a few months after the fact. I tried Tru Niagen NR 250 mg. May have already been said here, but apparently NR is currently the most effective NAD precursor to 'get inside' the cells and increase NAD+. Anyway I began taking the supplement, with absolutely no other changes in my diet/supplements/exercise/etc, and within 3 days I experienced the worst somnolence and fatigue of my entire life. Literally was sleeping 9 hours a night (I'm usually 7-8), and taking multiple naps during the day. I discontinued the supplement and the side effects disappeared within 36 hours. I gave the supplement the benefit of the doubt, and was open to the fact that perhaps I had caught some bug. Anyway, I started the supplement again about a week later and the exact same thing happened after just 2 days. Wanting to 'snap myself out of it' I took a mountain bike ride - literally the worst ride and likely the most dangerous I've been on, even though the trail was simple (not too steep and not technical); I had almost no energy and no focus. I stopped taking the supplement and of course within 24 hours I'm fine. There was a study showing mice that had their NAD+ levels boosted with NR had decreased exercise performance.... and it wasn't marginal. It was an average 35% less than the control group. And only one mouse on the NAD+ managed to surpass the median level of the control group. Wondering if this stuff, while showing anti-aging 'benefits,' comes at the price of basically shutting down the energy delivery systems (at least for people like me). Kind of like cryo-freeze or cryo-sleep in the movies. Again we are not rats and this is just my experience. I desperately wanted this stuff to work; I would have been fine and kept going on it even if I felt nothing, with the assumption that the benefits were taking place under the surface. Anyway there ya have it and here is the mouse/rat study: [URL="https://jissn.biomedcentral.com/articles/10.1186/s12970-016-0143-x"]The NAD + precursor nicotinamide riboside decreases exercise performance in rats[/URL] and [URL="https://blog.priceplow.com/supplement-news/niagen-decreases-performance"]Niagen Research Shows DECREASED Athletic Performance![/URL] [/QUOTE]
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