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General Health & Fitness
Nutrition and Supplements
NAD, Hype Or Miracle Molecule?
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<blockquote data-quote="JPB" data-source="post: 144901" data-attributes="member: 2659"><p>What I am essentially saying is that when you raise your NAM levels the NAD+ and sirtuin related pathways may and likely are temporarily suppressed. This is not a big deal when you coincide this with your bodies natural autonomic functions and keep your NAM supplementation cyclical. Think flight or fight during the day, rest and repair at night. The NAM will feed the energy expenditure cycle which is naturally catabolic, but "coil the spring" such that later in the day (and post-workout) the NAD+ and sirtuin pathways will rebound back into play, strongly. To coincide and support repair and anabolism. These are fairly advanced concepts and the research backup would take forever so I really don't want to debate these matters with those that may be so inclined, so I will just parlay this as my informed philosophy. Besides the essence of what I am saying regarding circadian cycles, more fundamentally this also allows overloaded channels to recycle (the conversion factors, etc). I would not advocate keeping NAM levels high 24x7, and believe it could certainly be counter-productive. The specific timing is to a degree conjecture.</p></blockquote><p></p>
[QUOTE="JPB, post: 144901, member: 2659"] What I am essentially saying is that when you raise your NAM levels the NAD+ and sirtuin related pathways may and likely are temporarily suppressed. This is not a big deal when you coincide this with your bodies natural autonomic functions and keep your NAM supplementation cyclical. Think flight or fight during the day, rest and repair at night. The NAM will feed the energy expenditure cycle which is naturally catabolic, but "coil the spring" such that later in the day (and post-workout) the NAD+ and sirtuin pathways will rebound back into play, strongly. To coincide and support repair and anabolism. These are fairly advanced concepts and the research backup would take forever so I really don't want to debate these matters with those that may be so inclined, so I will just parlay this as my informed philosophy. Besides the essence of what I am saying regarding circadian cycles, more fundamentally this also allows overloaded channels to recycle (the conversion factors, etc). I would not advocate keeping NAM levels high 24x7, and believe it could certainly be counter-productive. The specific timing is to a degree conjecture. [/QUOTE]
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General Health & Fitness
Nutrition and Supplements
NAD, Hype Or Miracle Molecule?
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