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NAD, Hype Or Miracle Molecule?
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<blockquote data-quote="Will Brink" data-source="post: 144788" data-attributes="member: 2074"><p>I have addressed that repeatedly, so either you're not as well informed as you think you are and or lack the sci/med background for the discussion, or you're intentionally being obtuse. Either way, you're now wasting my time at this point.</p><p></p><p>So yes, we will wait until there's further data to answer the Qs that need answering, and there's not much else to say. I'm more optimistic about the use of NR and other modalities to raise NAD+ due to aging, and you're convinced other approaches are as effective regardless of age and or in those diseases where higher levels of NAD+ may be of benefit.</p><p></p><p>Here some possibilities as to why NAD+ decline with age:</p><p></p><p>"...an NADase called CD38 whose levels rise during aging. Their results also add to the body of evidence indicating that loss of SIRT3 activity in mitochondria is a cause of age-related metabolic decline:</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088772/" target="_blank">Why NAD+ Declines during Aging: It’s Destroyed</a></p><p></p><p>And what is the rate limiting step to NAD+ production?</p><p></p><p>"nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in this pathway"</p><p></p><p>Best paper I have read so far on the age related decline and why:</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795269/" target="_blank">NAD + biosynthesis, aging, and disease</a></p><p></p><p>Hence again, as explained, bypassing the rate limiting step in a pathway, be it due to age and or possible benefits of doing so, is common approach to boosting various beneficial compounds.</p></blockquote><p></p>
[QUOTE="Will Brink, post: 144788, member: 2074"] I have addressed that repeatedly, so either you're not as well informed as you think you are and or lack the sci/med background for the discussion, or you're intentionally being obtuse. Either way, you're now wasting my time at this point. So yes, we will wait until there's further data to answer the Qs that need answering, and there's not much else to say. I'm more optimistic about the use of NR and other modalities to raise NAD+ due to aging, and you're convinced other approaches are as effective regardless of age and or in those diseases where higher levels of NAD+ may be of benefit. Here some possibilities as to why NAD+ decline with age: "...an NADase called CD38 whose levels rise during aging. Their results also add to the body of evidence indicating that loss of SIRT3 activity in mitochondria is a cause of age-related metabolic decline: [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088772/']Why NAD+ Declines during Aging: It’s Destroyed[/URL] And what is the rate limiting step to NAD+ production? "nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in this pathway" Best paper I have read so far on the age related decline and why: [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795269/']NAD + biosynthesis, aging, and disease[/URL] Hence again, as explained, bypassing the rate limiting step in a pathway, be it due to age and or possible benefits of doing so, is common approach to boosting various beneficial compounds. [/QUOTE]
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NAD, Hype Or Miracle Molecule?
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