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NAD, Hype Or Miracle Molecule?
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<blockquote data-quote="Will Brink" data-source="post: 144733" data-attributes="member: 2074"><p>Source? Niacinamide converts to NAD+/NADH, not the other way around, but may also increase Niacinamide in some tissue via tissue flux so the process is not one way apparantly. NAD+/NADH. NAD+ levels drop as we age substantially suggesting conversion of Niacinamide to NAD+ is reduced with age.</p><p></p><p>Typical of aging, conversion to active compounds from their precursors drops drastically so using what bypasses the limiting enyzyme(s) often takes care of that problem, or at least helps considerably.</p><p></p><p>Younger people unlikely to benefit from NR, as their conversion from precursors is GTG, there's also data to suggest there may be benefits to NR as the conversion, even in healthy people, it limited and NAD+ levels of "normal" may of value. There's many examples where aging reduced conversion to active compounds, and or, there may be benefits from bypassing the limiting enzymes to conversion, not unlike creatine vs precursors, EPA/DHA vs LNA, or Glu-cys moieties found in whey for increased GSH. The data suggests simply taking niacinamide is not equivalent to taking NR, especially in aging populations.</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/18429699#" target="_blank">Annu Rev Nutr.</a> 2008;28:115-30. doi: 10.1146/annurev.nutr.28.061807.155443.</p><p><span style="font-size: 26px">Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition.</span></p><p></p><p></p><p><span style="font-size: 18px">Abstract</span></p><p></p><p>Although baseline requirements for nicotinamide adenine dinucleotide (NAD+) synthesis can be met either with dietary tryptophan or with less than 20 mg of daily niacin, which consists of nicotinic acid and/or nicotinamide, there is growing evidence that substantially greater rates of NAD+ synthesis may be beneficial to protect against neurological degeneration, Candida glabrata infection, and possibly to enhance reverse cholesterol transport. The distinct and tissue-specific biosynthetic and/or ligand activities of tryptophan, nicotinic acid, nicotinamide, and the newly identified NAD+ precursor, nicotinamide riboside, reviewed herein, are responsible for vitamin-specific effects and side effects. Because current data suggest that nicotinamide riboside may be the only vitamin precursor that supports neuronal NAD+ synthesis, we present prospects for human nicotinamide riboside supplementation and propose areas for future research.</p></blockquote><p></p>
[QUOTE="Will Brink, post: 144733, member: 2074"] Source? Niacinamide converts to NAD+/NADH, not the other way around, but may also increase Niacinamide in some tissue via tissue flux so the process is not one way apparantly. NAD+/NADH. NAD+ levels drop as we age substantially suggesting conversion of Niacinamide to NAD+ is reduced with age. Typical of aging, conversion to active compounds from their precursors drops drastically so using what bypasses the limiting enyzyme(s) often takes care of that problem, or at least helps considerably. Younger people unlikely to benefit from NR, as their conversion from precursors is GTG, there's also data to suggest there may be benefits to NR as the conversion, even in healthy people, it limited and NAD+ levels of "normal" may of value. There's many examples where aging reduced conversion to active compounds, and or, there may be benefits from bypassing the limiting enzymes to conversion, not unlike creatine vs precursors, EPA/DHA vs LNA, or Glu-cys moieties found in whey for increased GSH. The data suggests simply taking niacinamide is not equivalent to taking NR, especially in aging populations. [URL='https://www.ncbi.nlm.nih.gov/pubmed/18429699#']Annu Rev Nutr.[/URL] 2008;28:115-30. doi: 10.1146/annurev.nutr.28.061807.155443. [SIZE=26px]Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition.[/SIZE] [SIZE=18px]Abstract[/SIZE] Although baseline requirements for nicotinamide adenine dinucleotide (NAD+) synthesis can be met either with dietary tryptophan or with less than 20 mg of daily niacin, which consists of nicotinic acid and/or nicotinamide, there is growing evidence that substantially greater rates of NAD+ synthesis may be beneficial to protect against neurological degeneration, Candida glabrata infection, and possibly to enhance reverse cholesterol transport. The distinct and tissue-specific biosynthetic and/or ligand activities of tryptophan, nicotinic acid, nicotinamide, and the newly identified NAD+ precursor, nicotinamide riboside, reviewed herein, are responsible for vitamin-specific effects and side effects. Because current data suggest that nicotinamide riboside may be the only vitamin precursor that supports neuronal NAD+ synthesis, we present prospects for human nicotinamide riboside supplementation and propose areas for future research. [/QUOTE]
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