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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
NAC Improved Response to Clomid in Women with PCOS
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<blockquote data-quote="Nelson Vergel" data-source="post: 73251" data-attributes="member: 3"><p>Send to</p><p>Fertil Steril. 2005 Feb;83(2):367-70.</p><p><span style="font-size: 12px"><strong>N-acetyl-cysteine is a novel adjuvant to clomiphene citrate in clomiphene citrate-resistant patients with polycystic ovary syndrome.</strong></span></p><p><span style="font-size: 12px"><strong></strong></span></p><p>Rizk AY1, Bedaiwy MA, Al-Inany HG.</p><p></p><p></p><p>Abstract</p><p>OBJECTIVE:</p><p>To evaluate the effect of N-acetyl-cysteine (NAC), a mucolytic drug with insulin sensitizing properties, as an adjuvant therapy in subjects with polycystic ovary syndrome (PCOS) resistant to clomiphene citrate (CC).</p><p></p><p>DESIGN:</p><p>Placebo-controlled, double-blind randomized trial.</p><p></p><p>SETTING:</p><p>University-based hospital and private infertility practice.</p><p></p><p>PATIENT(S):</p><p>One hundred fifty women diagnosed with CC-resistant PCOS, aged 18-39 years undergoing therapy for infertility were included.</p><p></p><p>INTERVENTION(S):</p><p>The patients were assigned randomly to receive either NAC 1.2 g/d (group I) or placebo (group II) with CC 100 mg/d for 5 days starting at day 3 of the cycle.</p><p></p><p>MAIN OUTCOME MEASURE(S):</p><p>Ovulation rate and pregnancy rate (PR).</p><p></p><p>RESULT(S):</p><p>Combination of CC and NAC significantly increased both ovulation rate and PR in women with CC-resistant PCOS (49.3% vs. 1.3% and 21.3% vs. 0%, respectively). No cases of ovarian hyperstimulation syndrome (OHSS) were reported in the NAC group; two cases of miscarriage (12.5%) were reported.</p><p></p><p>CONCLUSION(S):</p><p>The NAC as an adjuvant to CC was more effective than placebo for CC-resistant patients with PCOS. It is safe and well tolerated.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 73251, member: 3"] Send to Fertil Steril. 2005 Feb;83(2):367-70. [SIZE=3][B]N-acetyl-cysteine is a novel adjuvant to clomiphene citrate in clomiphene citrate-resistant patients with polycystic ovary syndrome. [/B][/SIZE] Rizk AY1, Bedaiwy MA, Al-Inany HG. Abstract OBJECTIVE: To evaluate the effect of N-acetyl-cysteine (NAC), a mucolytic drug with insulin sensitizing properties, as an adjuvant therapy in subjects with polycystic ovary syndrome (PCOS) resistant to clomiphene citrate (CC). DESIGN: Placebo-controlled, double-blind randomized trial. SETTING: University-based hospital and private infertility practice. PATIENT(S): One hundred fifty women diagnosed with CC-resistant PCOS, aged 18-39 years undergoing therapy for infertility were included. INTERVENTION(S): The patients were assigned randomly to receive either NAC 1.2 g/d (group I) or placebo (group II) with CC 100 mg/d for 5 days starting at day 3 of the cycle. MAIN OUTCOME MEASURE(S): Ovulation rate and pregnancy rate (PR). RESULT(S): Combination of CC and NAC significantly increased both ovulation rate and PR in women with CC-resistant PCOS (49.3% vs. 1.3% and 21.3% vs. 0%, respectively). No cases of ovarian hyperstimulation syndrome (OHSS) were reported in the NAC group; two cases of miscarriage (12.5%) were reported. CONCLUSION(S): The NAC as an adjuvant to CC was more effective than placebo for CC-resistant patients with PCOS. It is safe and well tolerated. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
NAC Improved Response to Clomid in Women with PCOS
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