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Nutrition and Supplements
NAC Benefits: HDL and More
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<blockquote data-quote="Nelson Vergel" data-source="post: 61718" data-attributes="member: 3"><p>More on NAC</p><p></p><p></p><p></p><p><span style="color: #000000"><span style="font-family: 'Arial'"><a href="https://www.ncbi.nlm.nih.gov/pubmed/23369637#" target="_blank">Trends Pharmacol Sci.</a> 2013 Mar;34(3):167-77. doi: 10.1016/j.tips.2013.01.001. Epub 2013 Jan 29.</span></span></p><p><strong>The promise of N-acetylcysteine in neuropsychiatry.</strong><span style="color: #000000"><span style="font-family: 'Arial'">Berk M1, Malhi GS, Gray LJ, Dean OM.</span></span></p><p><span style="color: #000000"><span style="font-family: 'Arial'"></span></span></p><p><span style="color: #000000"><span style="font-family: 'Arial'"></span></span></p><p><span style="color: #000000"><span style="font-family: 'Arial'">Abstract</span></span></p><p><span style="color: #000000"><span style="font-family: 'Arial'">N-Acetylcysteine (NAC) targets a diverse array of factors germane to the pathophysiology of multiple neuropsychiatric disorders including glutamatergic transmission, the antioxidant glutathione, neurotrophins, apoptosis, mitochondrial function, and inflammatory pathways. This review summarises the areas where the mechanisms of action of NAC overlap with known pathophysiological elements, and offers a précis of current literature regarding the use of NAC in disorders including cocaine, cannabis, and smoking addictions, Alzheimer's and Parkinson's diseases, autism, compulsive and grooming disorders, schizophrenia, depression, and bipolar disorder. There are positive trials of NAC in all these disorders, and although many of these require replication and are methodologically preliminary, this makes it one of the most promising drug candidates in neuropsychiatric disorders. The efficacy pattern of NAC interestingly shows little respect for the current diagnostic systems. Its benign tolerability profile, its action on multiple operative pathways, and the emergence of positive trial data make it an important target to investigate.</span></span></p><p></p><p></p><p></p><p>Full Paper: <a href="http://ponderapharma.com/wp-content/uploads/2014/06/The-promise-of-N-acetylcysteine-in-neuropsychiatry.pdf" target="_blank">http://ponderapharma.com/wp-content/uploads/2014/06/The-promise-of-N-acetylcysteine-in-neuropsychiatry.pdf</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 61718, member: 3"] More on NAC [COLOR=#000000][FONT=Arial][URL='https://www.ncbi.nlm.nih.gov/pubmed/23369637#']Trends Pharmacol Sci.[/URL] 2013 Mar;34(3):167-77. doi: 10.1016/j.tips.2013.01.001. Epub 2013 Jan 29.[/FONT][/COLOR] [B]The promise of N-acetylcysteine in neuropsychiatry.[/B][COLOR=#000000][FONT=Arial]Berk M1, Malhi GS, Gray LJ, Dean OM. Abstract N-Acetylcysteine (NAC) targets a diverse array of factors germane to the pathophysiology of multiple neuropsychiatric disorders including glutamatergic transmission, the antioxidant glutathione, neurotrophins, apoptosis, mitochondrial function, and inflammatory pathways. This review summarises the areas where the mechanisms of action of NAC overlap with known pathophysiological elements, and offers a précis of current literature regarding the use of NAC in disorders including cocaine, cannabis, and smoking addictions, Alzheimer's and Parkinson's diseases, autism, compulsive and grooming disorders, schizophrenia, depression, and bipolar disorder. There are positive trials of NAC in all these disorders, and although many of these require replication and are methodologically preliminary, this makes it one of the most promising drug candidates in neuropsychiatric disorders. The efficacy pattern of NAC interestingly shows little respect for the current diagnostic systems. Its benign tolerability profile, its action on multiple operative pathways, and the emergence of positive trial data make it an important target to investigate.[/FONT][/COLOR] Full Paper: [URL]http://ponderapharma.com/wp-content/uploads/2014/06/The-promise-of-N-acetylcysteine-in-neuropsychiatry.pdf[/URL] [/QUOTE]
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NAC Benefits: HDL and More
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