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General Health & Fitness
Nutrition and Supplements
NAC Benefits: HDL and More
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<blockquote data-quote="George-NYBC" data-source="post: 3987" data-attributes="member: 628"><p><strong>Pulmonary hypertension</strong></p><p></p><p></p><p></p><p>Chiming in here. The original article that this piece refers to may be found here:</p><p><a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952618/pdf/JCI0729444.pdf" target="_blank">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952618/pdf/JCI0729444.pdf</a></p><p>The concern is whether taking NAC can contribute to pulmonary hypertension. A number of issues make me a bit dubious. Aside from the fact that this is a stuy in mice, the dose they used of 10 mg/ml is much higher than a dose humans would use. The next question would be the degree to which NAC is converted into the SNOAC form that might increase risk, if it happens at all.</p><p></p><p>In another mouse study ( </p><p><a href="http://www.ncbi.nlm.nih.gov/pubmed/21103380" target="_blank">Gender differences in S-nitrosoglutathione reductase activity in the lung. - PubMed - NCBI</a> ), gender differences suggested female mice were protected from pulmonary hypertension using NAC.</p><p></p><p>In general, studies have shown that NAC is protective in various lung diseases and conditions (fat embolism, cystic fibrosis). Conditions like COPD can benefit from NAC ( <a href="http://www.ncbi.nlm.nih.gov/pubmed/24293993" target="_blank">Effect of high-dose N-acetylcysteine on airway geometry, inflammation, and oxidative stress in COPD patients. - PubMed - NCBI</a> ). However, only larger, longer term studies would be able to detect a particular risk of PH from the use of NAC. My best guess is the risk is negligible.</p></blockquote><p></p>
[QUOTE="George-NYBC, post: 3987, member: 628"] [B]Pulmonary hypertension[/B] Chiming in here. The original article that this piece refers to may be found here: [URL]http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952618/pdf/JCI0729444.pdf[/URL] The concern is whether taking NAC can contribute to pulmonary hypertension. A number of issues make me a bit dubious. Aside from the fact that this is a stuy in mice, the dose they used of 10 mg/ml is much higher than a dose humans would use. The next question would be the degree to which NAC is converted into the SNOAC form that might increase risk, if it happens at all. In another mouse study ( [URL="http://www.ncbi.nlm.nih.gov/pubmed/21103380"]Gender differences in S-nitrosoglutathione reductase activity in the lung. - PubMed - NCBI[/URL] ), gender differences suggested female mice were protected from pulmonary hypertension using NAC. In general, studies have shown that NAC is protective in various lung diseases and conditions (fat embolism, cystic fibrosis). Conditions like COPD can benefit from NAC ( [URL="http://www.ncbi.nlm.nih.gov/pubmed/24293993"]Effect of high-dose N-acetylcysteine on airway geometry, inflammation, and oxidative stress in COPD patients. - PubMed - NCBI[/URL] ). However, only larger, longer term studies would be able to detect a particular risk of PH from the use of NAC. My best guess is the risk is negligible. [/QUOTE]
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NAC Benefits: HDL and More
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