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Message: <blockquote data-quote="FunkOdyssey" data-source="post: 292807" data-attributes="member: 44064">Poor metabolic health is a major risk factor for prostate cancer, which results in high levels of insulin (one of the most potent growth factors for cancer), inflammation, etc.[URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/38260162/[/URL]TRT is not. Men with active prostate cancer are even being treated with TRT now without any adverse effects on progression or mortality:[URL unfurl="true"]https://pmc.ncbi.nlm.nih.gov/articles/PMC10874869/[/URL]Look into the saturation model of androgens in the prostate. It takes a very low level of serum testosterone (like serious hypogonadism) to produce intraprostate levels of DHT that fully saturate the AR receptors. Beyond that point, additional testosterone has no effect.  Your older observational studies making correlations between serum free T and prostate cancer risk are countered by far more relevant (to you) modern studies of TRT which show no increased risk of adverse prostate outcomes.</blockquote>

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