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Per several of my recent posts, I have been on cream for almost two months. But, I have been on Natesto in the past. Of all the forms of TRT, I think Natesto was the least likely to cause unpleasant side effects for me. Can anyone else chime in with their experience? I have been on T Cyp injections; T Enanth injections; Cream (varying doses and locations); and, Natesto. I have also been on very low dose HcG daily for a long time. My quick thoughts:

  • Upsides:
    • Natesto is very quick and easy
    • The pulsatile nature results in less shut down of endogenous production
    • From what I recall, there is very little E2 conversation and DHT remains in check
    • These reasons make it compelling as monotherapy
      • IE, one can just stop at any point and resume endogenous production or use an alternative form of TRT
    • Contrary to OP, I felt at times that it was actually good for mood and clarity (but not always - maybe variable dosing - see below)
  • Downsides:
    • Three times a day up the nose
    • cost (covered by my insurance, though
    • Not sure how much it impacts libido
    • Not sure if I am getting same dose every time
    • Wonder if it is necessary to clean out residue periodically, which is awkward

Would love to hear about others' experience with Natesto or the compounded nasal gel.


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