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I’m not sure that field of SNPs is researched far enough to be effective yet.  However, I have read that slow comt responds well to HydroxyB12 and also some adaptogens like Ashwagandha.  Who really knows though?


I know that my b12 and folate are low and that any Bcomplex makes me super angry within a few minutes.  I haven’t messed with folate but typically methyl types of supps make me feel bad.  I do think the COMT think has merit because anything that slows COMT (ecgc, green tea, etc) does make me feel truly awful, and this was before learning of my COMT defect.  I can recall one time I was in LA and had some special high end green tea and it basically put me down for the day. 


The only sources for help with these that I have found are Ben Lynch’s book Dirty Genes and Nutrahacker.  Amy Yasko seems to think that everyone needs to start with low dose Lithum OroTate before messing with b12 or folate.  Not sure how much merit that has either.


I have yet to mess with the HydroxyB12 but have it here on my counter.


I know to stay away from most stimulants, as I am very sensitive to those.


TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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