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I’m not sure that field of SNPs is researched far enough to be effective yet.  However, I have read that slow comt responds well to HydroxyB12 and also some adaptogens like Ashwagandha.  Who really knows though?


I know that my b12 and folate are low and that any Bcomplex makes me super angry within a few minutes.  I haven’t messed with folate but typically methyl types of supps make me feel bad.  I do think the COMT think has merit because anything that slows COMT (ecgc, green tea, etc) does make me feel truly awful, and this was before learning of my COMT defect.  I can recall one time I was in LA and had some special high end green tea and it basically put me down for the day. 


The only sources for help with these that I have found are Ben Lynch’s book Dirty Genes and Nutrahacker.  Amy Yasko seems to think that everyone needs to start with low dose Lithum OroTate before messing with b12 or folate.  Not sure how much merit that has either.


I have yet to mess with the HydroxyB12 but have it here on my counter.


I know to stay away from most stimulants, as I am very sensitive to those.


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