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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
My notes on Empower nasal T gel experiment
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<blockquote data-quote="BigBeard411" data-source="post: 231797" data-attributes="member: 43898"><p>I am beginning to look into this variation more. My thoughts are that administration is not optimal, therefore absorption may fluctuate. We may be underestimating how far up the applicator/gel should go.</p><p></p><p>The Natesto applicator reaches the soft part of the nose under the bone, if pushed up as far as it can go. It is above this region that is most vascular - the respiratory and olfactory region. This is where the drug should go in order to be absorbed effectively. </p><p></p><p>I think this is the reason why we are told to squeeze our nose as opposed to spread it with an applicator - the squeeze pushes the gel further up, higher than the tip of the applicator reaches.</p><p></p><p>The nasal vestibule is the lower softer part of your nose, defined as:</p><p> The area just inside the nostril (nose opening) that leads into the nasal cavity. The nasal vestibule is supported by the cartilage of the nose and lined with tissue that contains small, course hairs. These hairs help filter dust, sand, and other particles to keep them from entering the lungs.</p><p></p><p>This region has the least vasculature and therefore natesto would absorb very poorly there. </p><p>The region just above the vestibule is the nasal atrium, this is defined as:</p><p><strong> </strong>The anterior expanded portion of the middle meatus of the nose, just above the vestibule</p><p>This region is also very poor in drug delivery potential. The septum is also poorly vascularized, so application should be kept on the lateral walls of nasal cavity, but as deep inside as possible.</p><p></p><p>This contrasts with the nasal respiratory and olfactory region, which would be the optimal position, and are deeper in the nose </p><p>(<a href="https://drug-dev.com/nasal-delivery-a-promising-route-of-drug-delivery-to-the-brain-scientific-considerations-2/" target="_blank">NASAL DELIVERY - A Promising Route of Drug Delivery to the Brain: Scientific Considerations</a>)</p><p>[ATTACH=full]25092[/ATTACH]</p><p></p><p></p><p>[ATTACH=full]25093[/ATTACH]</p><p>[ATTACH=full]25094[/ATTACH]</p><p>[ATTACH=full]25095[/ATTACH]</p><p></p><p>I'll try applying Natesto as deep as it can go, and then see if there is improvement. Maybe we were not applying deep enough by trying to avoid the plastic-chemical taste and smell. I am also not sure how clear instructions for application are. </p><p>The idea that the gel should be as deep as possible also puts sense into their instructions of blowing your nose before application, because most of the mucus is deeper in the nasal cavity. A mucus lining would hamper penetration into the capillary system.</p><p></p><p>Not sure if this applies here. My testosterone levels are the same before and after TRT.</p></blockquote><p></p>
[QUOTE="BigBeard411, post: 231797, member: 43898"] I am beginning to look into this variation more. My thoughts are that administration is not optimal, therefore absorption may fluctuate. We may be underestimating how far up the applicator/gel should go. The Natesto applicator reaches the soft part of the nose under the bone, if pushed up as far as it can go. It is above this region that is most vascular - the respiratory and olfactory region. This is where the drug should go in order to be absorbed effectively. I think this is the reason why we are told to squeeze our nose as opposed to spread it with an applicator - the squeeze pushes the gel further up, higher than the tip of the applicator reaches. The nasal vestibule is the lower softer part of your nose, defined as: The area just inside the nostril (nose opening) that leads into the nasal cavity. The nasal vestibule is supported by the cartilage of the nose and lined with tissue that contains small, course hairs. These hairs help filter dust, sand, and other particles to keep them from entering the lungs. This region has the least vasculature and therefore natesto would absorb very poorly there. The region just above the vestibule is the nasal atrium, this is defined as: [B] [/B]The anterior expanded portion of the middle meatus of the nose, just above the vestibule This region is also very poor in drug delivery potential. The septum is also poorly vascularized, so application should be kept on the lateral walls of nasal cavity, but as deep inside as possible. This contrasts with the nasal respiratory and olfactory region, which would be the optimal position, and are deeper in the nose ([URL="https://drug-dev.com/nasal-delivery-a-promising-route-of-drug-delivery-to-the-brain-scientific-considerations-2/"]NASAL DELIVERY - A Promising Route of Drug Delivery to the Brain: Scientific Considerations[/URL]) [ATTACH type="full" width="353px"]25092[/ATTACH] [ATTACH type="full" width="295px"]25093[/ATTACH] [ATTACH type="full"]25094[/ATTACH] [ATTACH type="full" width="343px"]25095[/ATTACH] I'll try applying Natesto as deep as it can go, and then see if there is improvement. Maybe we were not applying deep enough by trying to avoid the plastic-chemical taste and smell. I am also not sure how clear instructions for application are. The idea that the gel should be as deep as possible also puts sense into their instructions of blowing your nose before application, because most of the mucus is deeper in the nasal cavity. A mucus lining would hamper penetration into the capillary system. Not sure if this applies here. My testosterone levels are the same before and after TRT. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
My notes on Empower nasal T gel experiment
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