ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
My notes on Empower nasal T gel experiment
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 231737" data-attributes="member: 13851"><p>Not happening with daily/EOD prop.</p><p></p><p>Natesto PK profile vs prop let alone water-based suspension.....day and night!</p><p></p><p></p><p><em><strong>*The 24-hour pharmacokinetic profile of testosterone for patients on TNG treatment has two or three discrete peaks (“pulses”) of testosterone provoked by LH secretions that occur on average every 2 hours. A <u>maximal peak of testosterone appears at about 1h (Tmax) followed by a return to endogenous, pre-dose levels, 4-6 hours later (t1/2 ~1h)</u>. The nadir (trough) between doses correlates well with pre-treatment endogenous levels at diagnosis</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*The unique, pulsatile, pharmacokinetic profile is believed to have a limited impact on the HPG axis with <u>significant trough time preserving luteinizing hormone (LH), follicle-stimulating hormone (FSH), endogenous testosterone production, and sperm counts, while also limiting excess RBC production, estradiol, DHT and PSA in clinical trials</u></strong></em></p><p><em><strong></strong></em></p><p><em><strong>*In between NATESTO® doses, all patients in the phase 3 study maintained their natural testosterone at the same levels they had prior to entry into the study, indicating that NATESTO® does not suppress natural testosterone production. Based on the data, Acerus believes that the<u> mechanism of action of NATESTO® is unique whereby the peaks in testosterone generated by NATESTO® dosing provide efficacy and improvement of symptoms, while the time between doses (4-8 hours) allows for the maintenance of testicular testosterone production and sperm production</u></strong></em></p><p><em><strong></strong></em></p><p><em><strong>*Nasal administration of T (4.5% testosterone nasal gel, Natesto) <u>allows for rapid absorption through the nasal mucosa such that serum T levels reach a peak concentration in ∼40 min. Once in circulation, the T is quickly metabolized, with a return to near baseline T levels in 3–6 h</u> (11). Therefore, multiple administrations of nasal T throughout the day (three times daily) maintain normal mean serum T levels over 24 h. The fluctuations in T levels potentially minimize the duration of exposure to exogenous T that is suppressive to the HPG axis, compared to other available T therapies</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*Endocrine systems are regulated dynamically in response to positive or negative stimuli within a homeostatic environment. Modalities of T therapy evolved to extend the dosing interval and maintain sustained “steady-state” T levels. Long-acting TTh can inhibit the HPG axis, which in turn suppresses pituitary LH and FSH secretion, reducing circulating levels of LH and FSH and endogenous T production</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*Short-acting T therapy, consisting of several doses of T with a <u>shorter half-life throughout the day, minimizes inhibition of the HPG axis and reduces the impairment of spermatogenesis</u></strong></em></p><p></p><p></p><p></p><p></p><p><strong><em>post #55</em></strong></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/microdosing-enanthate.24640/page-3#post-215284[/URL]</p><p></p><p></p><p><strong><em>post #8</em></strong></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/unorthodox-cycle-idea.25591/#post-227677[/URL]</p><p></p><p></p><p><strong><em>post #68/70/72</em></strong></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/tips-on-how-to-blend-propionate-with-enanthate-or-cypionate.23485/page-4#post-205344[/URL]</p></blockquote><p></p>
[QUOTE="madman, post: 231737, member: 13851"] Not happening with daily/EOD prop. Natesto PK profile vs prop let alone water-based suspension.....day and night! [I][B]*The 24-hour pharmacokinetic profile of testosterone for patients on TNG treatment has two or three discrete peaks (“pulses”) of testosterone provoked by LH secretions that occur on average every 2 hours. A [U]maximal peak of testosterone appears at about 1h (Tmax) followed by a return to endogenous, pre-dose levels, 4-6 hours later (t1/2 ~1h)[/U]. The nadir (trough) between doses correlates well with pre-treatment endogenous levels at diagnosis *The unique, pulsatile, pharmacokinetic profile is believed to have a limited impact on the HPG axis with [U]significant trough time preserving luteinizing hormone (LH), follicle-stimulating hormone (FSH), endogenous testosterone production, and sperm counts, while also limiting excess RBC production, estradiol, DHT and PSA in clinical trials[/U] *In between NATESTO® doses, all patients in the phase 3 study maintained their natural testosterone at the same levels they had prior to entry into the study, indicating that NATESTO® does not suppress natural testosterone production. Based on the data, Acerus believes that the[U] mechanism of action of NATESTO® is unique whereby the peaks in testosterone generated by NATESTO® dosing provide efficacy and improvement of symptoms, while the time between doses (4-8 hours) allows for the maintenance of testicular testosterone production and sperm production[/U] *Nasal administration of T (4.5% testosterone nasal gel, Natesto) [U]allows for rapid absorption through the nasal mucosa such that serum T levels reach a peak concentration in ∼40 min. Once in circulation, the T is quickly metabolized, with a return to near baseline T levels in 3–6 h[/U] (11). Therefore, multiple administrations of nasal T throughout the day (three times daily) maintain normal mean serum T levels over 24 h. The fluctuations in T levels potentially minimize the duration of exposure to exogenous T that is suppressive to the HPG axis, compared to other available T therapies *Endocrine systems are regulated dynamically in response to positive or negative stimuli within a homeostatic environment. Modalities of T therapy evolved to extend the dosing interval and maintain sustained “steady-state” T levels. Long-acting TTh can inhibit the HPG axis, which in turn suppresses pituitary LH and FSH secretion, reducing circulating levels of LH and FSH and endogenous T production *Short-acting T therapy, consisting of several doses of T with a [U]shorter half-life throughout the day, minimizes inhibition of the HPG axis and reduces the impairment of spermatogenesis[/U][/B][/I] [B][I]post #55[/I][/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/microdosing-enanthate.24640/page-3#post-215284[/URL] [B][I]post #8[/I][/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/unorthodox-cycle-idea.25591/#post-227677[/URL] [B][I]post #68/70/72[/I][/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/tips-on-how-to-blend-propionate-with-enanthate-or-cypionate.23485/page-4#post-205344[/URL] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
My notes on Empower nasal T gel experiment
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top