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A CIMT (Carotid Intima Media Thickness test) can detect soft plaque in the carotid artery.  There is supposedly a 90 some % correlation of carotid plaque w/ the amount found in your arterial tree.  So whatever soft plaque is found in the carotid, you supposedly can assume roughly the same amount in the rest of your arteries.  The CIMT uses ultrasound and is completely non-invasive.