ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
My 6 weeks TRT Labs: advise welcome
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Cataceous" data-source="post: 260055" data-attributes="member: 38109"><p>While both estradiol and hematocrit respond to serum testosterone, they respond on different time scales. This may or may not matter. If you're looking to minimize estradiol peaks at a given dose then more frequent injections of a long testosterone ester should yield the "best" result. As a side note, there are quite a few anecdotal reports of less estrogenic activity with daily use of testosterone propionate. If this is real then it suggests greater complexity. At the least we should ask whether a given effect is driven by peak, average, or trough hormone levels—or some combination—along with duration of exposure.</p><p></p><p></p><p>With 3x/week injections spaced at 2/2/3 days the three cycles are unique in their peak/trough variations. Without jumping into the math I'm going to guess that the three-day cycle could still see a peak that's as much as 40% over the trough. However, I can also mention that on EOD injections of a longer ester I could not discern any variation; pre-injection and day-after injection measurements seemed to be about the same. If you want more certainty then you have to measure your levels.</p><p></p><p>If symptoms do not resolve with levels in the normal range then one's efforts should be directed towards understanding why. In my opinion throwing more testosterone at the problem is not a good approach.</p><p></p><p></p><p>You will find plenty of guys saying they find one way or the other to be better. It's not clear if these would be sustained if blinded testing were possible. Of course the same skepticism should be directed at my preferred protocol—daily injections of a propionate/enanthate blend designed to create a diurnal rhythm in serum testosterone. While I am pretty confident that my sleep is better compared to when I had stable levels, other benefits are too subtle to be sure about.</p><p></p><p></p><p><a href="https://www.excelmale.com/forum/threads/how-to-predict-estradiol-and-dht-at-different-testosterone-doses.20830/" target="_blank">Here</a> are formulas for estimating total estradiol and DHT based on total testosterone. Maybe [USER=38590]@tareload[/USER] can point to a more general pharmacokinetic calculator for testosterone cypionate? Alternatively, or in addition, I've found it's possible to generate some pretty decent predictions with crude calculations based on one's own lab work. The first step is to estimate a constant of proportionality <em>k</em> such that free testosterone is the product of <em>k</em> and the dose rate. This is best accomplished with relatively frequent dosing with a long ester. As I mentioned, for me EOD dosing with cypionate or enanthate yielded consistent results. I have found that with the constant <em>k</em> and a trough testosterone measurement you can calculate a reasonable estimate of the peak.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 260055, member: 38109"] While both estradiol and hematocrit respond to serum testosterone, they respond on different time scales. This may or may not matter. If you're looking to minimize estradiol peaks at a given dose then more frequent injections of a long testosterone ester should yield the "best" result. As a side note, there are quite a few anecdotal reports of less estrogenic activity with daily use of testosterone propionate. If this is real then it suggests greater complexity. At the least we should ask whether a given effect is driven by peak, average, or trough hormone levels—or some combination—along with duration of exposure. With 3x/week injections spaced at 2/2/3 days the three cycles are unique in their peak/trough variations. Without jumping into the math I'm going to guess that the three-day cycle could still see a peak that's as much as 40% over the trough. However, I can also mention that on EOD injections of a longer ester I could not discern any variation; pre-injection and day-after injection measurements seemed to be about the same. If you want more certainty then you have to measure your levels. If symptoms do not resolve with levels in the normal range then one's efforts should be directed towards understanding why. In my opinion throwing more testosterone at the problem is not a good approach. You will find plenty of guys saying they find one way or the other to be better. It's not clear if these would be sustained if blinded testing were possible. Of course the same skepticism should be directed at my preferred protocol—daily injections of a propionate/enanthate blend designed to create a diurnal rhythm in serum testosterone. While I am pretty confident that my sleep is better compared to when I had stable levels, other benefits are too subtle to be sure about. [URL='https://www.excelmale.com/forum/threads/how-to-predict-estradiol-and-dht-at-different-testosterone-doses.20830/']Here[/URL] are formulas for estimating total estradiol and DHT based on total testosterone. Maybe [USER=38590]@tareload[/USER] can point to a more general pharmacokinetic calculator for testosterone cypionate? Alternatively, or in addition, I've found it's possible to generate some pretty decent predictions with crude calculations based on one's own lab work. The first step is to estimate a constant of proportionality [I]k[/I] such that free testosterone is the product of [I]k[/I] and the dose rate. This is best accomplished with relatively frequent dosing with a long ester. As I mentioned, for me EOD dosing with cypionate or enanthate yielded consistent results. I have found that with the constant [I]k[/I] and a trough testosterone measurement you can calculate a reasonable estimate of the peak. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
My 6 weeks TRT Labs: advise welcome
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top