ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
MPB and Finasteride (side effects/dosing theory)
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 215047" data-attributes="member: 13851"><p><strong>4. Impact of 5α-reductase inhibitors on sexual function</strong></p><p></p><p></p><p><em><strong><u>5-ARIs, mainly including finasteride and dutasteride, represent a class of drugs that competitively inhibit 5-alpha reductase isoenzymes (5-ARs)</u>. In humans, three types of 5-ARs have been described so far: type-1 is temporarily expressed in newborn skin and scalp and is permanently detectable in the skin after puberty onset; type-2 localizes predominately in fetal genital skin and male accessory glands including prostate [40]; type-3 is expressed both into androgen-dependent tissues (e.g. smooth muscle and prostate) and in the brain, heart, and other peripheral tissues [41].</strong></em></p><p><em><strong></strong></em></p><p><em><strong>In vitro experiments have shown a higher inhibitory activity of dutasteride on type 3 than type 2( 5-ARs). By contrast, these isoenzymes are similarly sensitive to finasteride [41]. <u>Several mechanisms have to be considered when the impact of 5-ARIs on sexual function is considered</u>.</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*First of all, dihydrotestosterone (DHT) more effectively than T enhances nitric oxide (NO) availability in the endothelium [42]. <u>Thus, 5-ARIs can indirectly reduce the peripheral amount of NO concentration and, consequently, have a negative impact on erection</u>.</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*<u>The reduction in DHT explains the reduced volume of ejaculate experienced by treated patients and, in addition, these drugs are able to prevent the conversion of progesterone and deoxycorticosterone into neurosteroids</u>, <u>the latter playing a role in regulating mood, anxiety, sleep, and sexual function</u> [43,44].</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*<u>Finally, finasteride can exert a central effect by crossing the blood-brain barrier and reducing the hormonal impregnation of the central nervous system </u>[45,46].</strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 215047, member: 13851"] [B]4. Impact of 5α-reductase inhibitors on sexual function[/B] [I][B][U]5-ARIs, mainly including finasteride and dutasteride, represent a class of drugs that competitively inhibit 5-alpha reductase isoenzymes (5-ARs)[/U]. In humans, three types of 5-ARs have been described so far: type-1 is temporarily expressed in newborn skin and scalp and is permanently detectable in the skin after puberty onset; type-2 localizes predominately in fetal genital skin and male accessory glands including prostate [40]; type-3 is expressed both into androgen-dependent tissues (e.g. smooth muscle and prostate) and in the brain, heart, and other peripheral tissues [41]. In vitro experiments have shown a higher inhibitory activity of dutasteride on type 3 than type 2( 5-ARs). By contrast, these isoenzymes are similarly sensitive to finasteride [41]. [U]Several mechanisms have to be considered when the impact of 5-ARIs on sexual function is considered[/U]. *First of all, dihydrotestosterone (DHT) more effectively than T enhances nitric oxide (NO) availability in the endothelium [42]. [U]Thus, 5-ARIs can indirectly reduce the peripheral amount of NO concentration and, consequently, have a negative impact on erection[/U]. *[U]The reduction in DHT explains the reduced volume of ejaculate experienced by treated patients and, in addition, these drugs are able to prevent the conversion of progesterone and deoxycorticosterone into neurosteroids[/U], [U]the latter playing a role in regulating mood, anxiety, sleep, and sexual function[/U] [43,44]. *[U]Finally, finasteride can exert a central effect by crossing the blood-brain barrier and reducing the hormonal impregnation of the central nervous system [/U][45,46].[/B][/I] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
MPB and Finasteride (side effects/dosing theory)
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top