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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
MPB and Finasteride (side effects/dosing theory)
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<blockquote data-quote="Cataceous" data-source="post: 215041" data-attributes="member: 38109"><p>Your idea about the buildup isn't quite right. With a half-life of only six hours, finasteride will basically be at steady state in under two days. There's no additional buildup from daily dosing. The effect on DHT is more complicated. Its binding of the 5ar enzyme is pretty much irreversible. Thus the effects will depend on the dose and the creation rate of 5ar. Per Wiki it takes very little to get the maximum result: "An oral dosage of finasteride of only 0.2 mg/day has been found to achieve near-maximal suppression of DHT levels (68.6% for 0.2 mg/day relative to 72.2% for 5 mg/day). Finasteride does not completely suppress DHT production because it lacks significant inhibitory effects on the 5α-reductase type I isoenzyme, with more than 100-fold less inhibitory potency for type I as compared to type II ..."</p></blockquote><p></p>
[QUOTE="Cataceous, post: 215041, member: 38109"] Your idea about the buildup isn't quite right. With a half-life of only six hours, finasteride will basically be at steady state in under two days. There's no additional buildup from daily dosing. The effect on DHT is more complicated. Its binding of the 5ar enzyme is pretty much irreversible. Thus the effects will depend on the dose and the creation rate of 5ar. Per Wiki it takes very little to get the maximum result: "An oral dosage of finasteride of only 0.2 mg/day has been found to achieve near-maximal suppression of DHT levels (68.6% for 0.2 mg/day relative to 72.2% for 5 mg/day). Finasteride does not completely suppress DHT production because it lacks significant inhibitory effects on the 5α-reductase type I isoenzyme, with more than 100-fold less inhibitory potency for type I as compared to type II ..." [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
MPB and Finasteride (side effects/dosing theory)
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