No difference. When I was T mono my E2 and prolactin went quite high. The AI(.125) was taken EOD. Once my lvl were back in range I dropped back to M/T (.125x2)
Every now and then I will get what I call an E2 wave of emotion and I will take a 3rd pill. The emotion fades in 4 hours.
did that help or were you asking about my M/W/F T injections? Because I have always done 3 days a week and never tried twice a week.