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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Most Patients Liked Being Switched to Subcutaneous Testosterone Injections
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<blockquote data-quote="madman" data-source="post: 223354" data-attributes="member: 13851"><p><strong>Early Experience with Subcutaneous Injection of Non-Proprietary Testosterone as an Alternative Approach for Testosterone Replacement (2022)</strong></p><p><em>KAlter, DRoadman, CAmarasekera, LLevine</em></p><p></p><p></p><p><strong>Introduction</strong></p><p></p><p><em>Testosterone replacement therapy (TRT) has been demonstrated to benefit men with a diagnosis of hypogonadism. <strong>We elected to offer a non-proprietary subcutaneous injection (subQ) using a ½ inch 27g needle for TRT as an alternative treatment for hypogonadism.</strong></em></p><p></p><p></p><p><strong>Objective</strong></p><p></p><p><em><strong>To investigate the effect of subQ TRT in hypogonadal men, in order to compare satisfaction, HCT, and PSA levels to other forms of TRT.</strong></em></p><p></p><p>[ATTACH=full]41540[/ATTACH]</p><p><strong>Methods</strong></p><p></p><p><em><strong>The study period was defined as the most recent follow-up appointment after beginning subQ TRT with a mean follow-up of 4.2 months (range 1-6 months). Variables were obtained prior to beginning subQ TRT and at the last follow-up visit. Patients either began subQ TRT primarily or switched from another method. Additionally, patients completed a satisfaction survey. Statistical analysis was performed with SPSS 24. Associations between testosterone levels and clinical variables were analyzed by univariate analysis.</strong></em></p><p></p><p></p><p><strong>Results</strong></p><p></p><p><em><strong>32 total patients received subQ TRT. Pre and post-subQ TRT testosterone levels (increased 299.7 +/- 61.5), HCT levels (increased 0.8 +/- 1.0%), PSA levels (increased 0.87 +/- 0.3 ng/mL), AUASS (decreased 3.7 +/- 1.7), and SHIM scores (increased 2.1 +/- 2.4) were recorded (Table 1). 21 patients received other forms of TRT prior to beginning subQ TRT and variables were collected and analyzed (Table 2). Overall, 21 patients completed the follow-up satisfaction survey. 19 (90.5%) were satisfied with subQ TRT and 2 (9.5%) patients attributed their dissatisfaction to greater symptom improvement on previous therapies (Testopel, Jatenzo). 11 (84.6%) patients reported better or same satisfaction on subQ TRT than with prior therapy. Furthermore, 8 (88.9%) patients said subQ TRT was easier to use than prior TRT injection (Intramuscular and Testopel), while 1 (11.1%) patient preferred fewer treatments with Testopel. Lastly, all patients reported subQ TRT as less painful during administration.</strong></em></p><p></p><p></p><p><strong>Conclusions</strong></p><p></p><p><em><strong>SubQ TRT led to higher testosterone levels, positive satisfaction scores, and improved AUASS and SHIM scores at the most recent follow-up. There was also no significant change to HCT or PSA levels. Ongoing monitoring focusing on longer duration of follow-up, erythrocytosis, satisfaction, and side effects are being conducted and will be reported.</strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 223354, member: 13851"] [B]Early Experience with Subcutaneous Injection of Non-Proprietary Testosterone as an Alternative Approach for Testosterone Replacement (2022)[/B] [I]KAlter, DRoadman, CAmarasekera, LLevine[/I] [B]Introduction[/B] [I]Testosterone replacement therapy (TRT) has been demonstrated to benefit men with a diagnosis of hypogonadism. [B]We elected to offer a non-proprietary subcutaneous injection (subQ) using a ½ inch 27g needle for TRT as an alternative treatment for hypogonadism.[/B][/I] [B]Objective[/B] [I][B]To investigate the effect of subQ TRT in hypogonadal men, in order to compare satisfaction, HCT, and PSA levels to other forms of TRT.[/B][/I] [ATTACH type="full"]41540[/ATTACH] [B]Methods[/B] [I][B]The study period was defined as the most recent follow-up appointment after beginning subQ TRT with a mean follow-up of 4.2 months (range 1-6 months). Variables were obtained prior to beginning subQ TRT and at the last follow-up visit. Patients either began subQ TRT primarily or switched from another method. Additionally, patients completed a satisfaction survey. Statistical analysis was performed with SPSS 24. Associations between testosterone levels and clinical variables were analyzed by univariate analysis.[/B][/I] [B]Results[/B] [I][B]32 total patients received subQ TRT. Pre and post-subQ TRT testosterone levels (increased 299.7 +/- 61.5), HCT levels (increased 0.8 +/- 1.0%), PSA levels (increased 0.87 +/- 0.3 ng/mL), AUASS (decreased 3.7 +/- 1.7), and SHIM scores (increased 2.1 +/- 2.4) were recorded (Table 1). 21 patients received other forms of TRT prior to beginning subQ TRT and variables were collected and analyzed (Table 2). Overall, 21 patients completed the follow-up satisfaction survey. 19 (90.5%) were satisfied with subQ TRT and 2 (9.5%) patients attributed their dissatisfaction to greater symptom improvement on previous therapies (Testopel, Jatenzo). 11 (84.6%) patients reported better or same satisfaction on subQ TRT than with prior therapy. Furthermore, 8 (88.9%) patients said subQ TRT was easier to use than prior TRT injection (Intramuscular and Testopel), while 1 (11.1%) patient preferred fewer treatments with Testopel. Lastly, all patients reported subQ TRT as less painful during administration.[/B][/I] [B]Conclusions[/B] [I][B]SubQ TRT led to higher testosterone levels, positive satisfaction scores, and improved AUASS and SHIM scores at the most recent follow-up. There was also no significant change to HCT or PSA levels. Ongoing monitoring focusing on longer duration of follow-up, erythrocytosis, satisfaction, and side effects are being conducted and will be reported.[/B][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Most Patients Liked Being Switched to Subcutaneous Testosterone Injections
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