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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
More Evidence of Declining Testosterone During Last Decades
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<blockquote data-quote="Cataceous" data-source="post: 237332" data-attributes="member: 38109"><p>Although the idea seems logical, as noted in Vince's link, the evidence is tending against this hypothesis.</p><p></p><p style="margin-left: 20px"><em>However, this adipose tissue-aromatase hypothesis is not well supported by other data. Clinical studies showing that treatment of obese men with aromatase inhibitors can increase testosterone levels and restore fertility do not necessarily support the pathophysiological importance of this E2-mediated hypothalamic-pituitary-testicular (HPT) axis suppression, because gonadotropins and testosterone levels also rise with this treatment. Interestingly, more recent studies suggest that, <strong>diabetic obesity is associated with decreases in circulatory E2</strong>. Moreover, there is evidence from the EMAS that <strong>even in nondiabetic obese men, E2 is low</strong> and correlated with low testosterone levels. In addition to E2, increased visceral fat also releases increased amounts of pro-inflammatory cytokines, insulin and leptin; all of which may inhibit the activity of the HPT axis at multiple levels.</em></p></blockquote><p></p>
[QUOTE="Cataceous, post: 237332, member: 38109"] Although the idea seems logical, as noted in Vince's link, the evidence is tending against this hypothesis. [INDENT][I]However, this adipose tissue-aromatase hypothesis is not well supported by other data. Clinical studies showing that treatment of obese men with aromatase inhibitors can increase testosterone levels and restore fertility do not necessarily support the pathophysiological importance of this E2-mediated hypothalamic-pituitary-testicular (HPT) axis suppression, because gonadotropins and testosterone levels also rise with this treatment. Interestingly, more recent studies suggest that, [B]diabetic obesity is associated with decreases in circulatory E2[/B]. Moreover, there is evidence from the EMAS that [B]even in nondiabetic obese men, E2 is low[/B] and correlated with low testosterone levels. In addition to E2, increased visceral fat also releases increased amounts of pro-inflammatory cytokines, insulin and leptin; all of which may inhibit the activity of the HPT axis at multiple levels.[/I][/INDENT] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
More Evidence of Declining Testosterone During Last Decades
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