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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Microdosing Enanthate
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<blockquote data-quote="madman" data-source="post: 216275" data-attributes="member: 13851"><p>Come again?</p><p></p><p>The use of exogenous T whether pellets, oral, patch, buccal, transdermal (gel/cream), <strong><em>injectable (short, medium, or long-acting esters),</em></strong> will result in suppression of the HPG axis.</p><p></p><p>Natesto would be considered the least suppressive due to the short-lived peaks/significant trough times between doses.</p><p></p><p></p><p><em><strong>* </strong></em><strong><em>All formulations, with the exception of the short-acting ones, <u>have a target of long-term maintenance of SUSTAINED STEADY-STATE TESTOSTERONE LEVELS IN THE MID-NORMAL RANGE</u>, which leads to suppression of the endogenous activity of the HPG axis</em></strong></p><p><strong><em></em></strong></p><p><strong><em>*The inhibition of HPG axis activity is evidenced by the <u>nearly full suppression of gonadotropin levels following treatment with either IM injectable testosterone (10) or topical gel administration</u> (9).</em></strong></p><p><strong><em></em></strong></p><p><strong><em></em></strong></p><p><strong><em></em></strong></p><p><strong><em>This is key:<strong><em> <u>long-term maintenance of sustained steady-state testosterone levels in the mid-normal range</u>, which leads to suppression of the endogenous activity of the HPG axis.</em></strong></em></strong></p><p><strong><em><strong><em></em></strong></em></strong></p><p><strong><em><strong><em><u>Topical gel formulations achieve a sustained mid-normal T level with a once-daily application</u> (8). While the topical gel results in less fluctuation of T levels between dosing intervals when compared to IM T, <u>the sustained T levels result in inhibition of HPG axis activity</u> (9). </em></strong>The inhibition of HPG axis activity is evidenced by the nearly full suppression of gonadotropin levels following treatment with either IM injectable testosterone (10) or topical gel administration (9).</em></strong></p><p></p><p></p><p></p><p><em>[URL unfurl="true"]https://www.excelmale.com/forum/threads/short-acting-t-therapy-to-maintain-homeostasis-that-more-closely-reflects-normal-physiology.22083/[/URL]</em></p><p></p><p><strong>post #78-81</strong></p><p><em>[URL unfurl="true"]https://www.excelmale.com/forum/threads/advice-on-low-dose-daily-testosterone.22096/page-4[/URL]</em></p></blockquote><p></p>
[QUOTE="madman, post: 216275, member: 13851"] Come again? The use of exogenous T whether pellets, oral, patch, buccal, transdermal (gel/cream), [B][I]injectable (short, medium, or long-acting esters),[/I][/B] will result in suppression of the HPG axis. Natesto would be considered the least suppressive due to the short-lived peaks/significant trough times between doses. [I][B]* [/B][/I][B][I]All formulations, with the exception of the short-acting ones, [U]have a target of long-term maintenance of SUSTAINED STEADY-STATE TESTOSTERONE LEVELS IN THE MID-NORMAL RANGE[/U], which leads to suppression of the endogenous activity of the HPG axis *The inhibition of HPG axis activity is evidenced by the [U]nearly full suppression of gonadotropin levels following treatment with either IM injectable testosterone (10) or topical gel administration[/U] (9). This is key:[B][I] [U]long-term maintenance of sustained steady-state testosterone levels in the mid-normal range[/U], which leads to suppression of the endogenous activity of the HPG axis. [U]Topical gel formulations achieve a sustained mid-normal T level with a once-daily application[/U] (8). While the topical gel results in less fluctuation of T levels between dosing intervals when compared to IM T, [U]the sustained T levels result in inhibition of HPG axis activity[/U] (9). [/I][/B]The inhibition of HPG axis activity is evidenced by the nearly full suppression of gonadotropin levels following treatment with either IM injectable testosterone (10) or topical gel administration (9).[/I][/B] [I][URL unfurl="true"]https://www.excelmale.com/forum/threads/short-acting-t-therapy-to-maintain-homeostasis-that-more-closely-reflects-normal-physiology.22083/[/URL][/I] [B]post #78-81[/B] [I][URL unfurl="true"]https://www.excelmale.com/forum/threads/advice-on-low-dose-daily-testosterone.22096/page-4[/URL][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
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Microdosing Enanthate
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