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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Microdosing Enanthate
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<blockquote data-quote="Cataceous" data-source="post: 214891" data-attributes="member: 38109"><p>One issue is that the test for the older range was not harmonized. But let's take a closer look at its <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146796/" target="_blank">source</a>. The mean free testosterone for this young cohort is 14.2 ng/dL. Question: What total testosterone does this correspond to when SHBG is average, about 30 nMol/L? Answer: 625 ng/dL. What about two standard deviations higher, at the top of the reference range? Answer: 940 ng/dL. This demonstrates that the high end of total testosterone is skewed by individuals with elevated SHBG.</p><p></p><p>It's assumed that higher body fat in participants in the newer study leads to higher estradiol and lower testosterone production. However, another factor is that BMI is negatively associated with SHBG. Lower SHBG drives down total testosterone even as the production rate stays the same.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 214891, member: 38109"] One issue is that the test for the older range was not harmonized. But let's take a closer look at its [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146796/']source[/URL]. The mean free testosterone for this young cohort is 14.2 ng/dL. Question: What total testosterone does this correspond to when SHBG is average, about 30 nMol/L? Answer: 625 ng/dL. What about two standard deviations higher, at the top of the reference range? Answer: 940 ng/dL. This demonstrates that the high end of total testosterone is skewed by individuals with elevated SHBG. It's assumed that higher body fat in participants in the newer study leads to higher estradiol and lower testosterone production. However, another factor is that BMI is negatively associated with SHBG. Lower SHBG drives down total testosterone even as the production rate stays the same. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Microdosing Enanthate
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