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Mental Health
Methylene Blue
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<blockquote data-quote="sammmy" data-source="post: 254385" data-attributes="member: 38594"><p>A dose of 138mg/day caused much more side effects in Alzheimer patients than placebo - about 1/3 of the study participants dropped the drug due to Adverse Events.</p><p></p><p>The adverse events were diarrhea (as I said it is cytotoxic to intestines at even the smallest doses), it is "poorly tolerated without food" (damages intestines), discomfort urinating, frequent urination, falls, decrease in red cell counts and hemoglobin, decrease in white blood cell counts.</p><p></p><p>These effects do not pass as "beneficial" in my book. It may be an acceptable tradeoff to an Alzheimer patient if the drug really slows their cognition decline but to someone without Alzheimer, such side effects indicate unacceptable toxicity.</p><p></p><p>The higher dose 228mg/day failed to give improvement on the Alzheimer scales, probably because of higher toxicity. The authors start in the Discussion section some medical mambo-jumbo to "explain" that rather unwanted "result".</p><p></p><p>Read the Safety section and look at the graphs for the improvement:</p><p></p><p>[URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/25550228/[/URL]</p></blockquote><p></p>
[QUOTE="sammmy, post: 254385, member: 38594"] A dose of 138mg/day caused much more side effects in Alzheimer patients than placebo - about 1/3 of the study participants dropped the drug due to Adverse Events. The adverse events were diarrhea (as I said it is cytotoxic to intestines at even the smallest doses), it is "poorly tolerated without food" (damages intestines), discomfort urinating, frequent urination, falls, decrease in red cell counts and hemoglobin, decrease in white blood cell counts. These effects do not pass as "beneficial" in my book. It may be an acceptable tradeoff to an Alzheimer patient if the drug really slows their cognition decline but to someone without Alzheimer, such side effects indicate unacceptable toxicity. The higher dose 228mg/day failed to give improvement on the Alzheimer scales, probably because of higher toxicity. The authors start in the Discussion section some medical mambo-jumbo to "explain" that rather unwanted "result". Read the Safety section and look at the graphs for the improvement: [URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/25550228/[/URL] [/QUOTE]
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