I’m on Tirzepatide (Mounjaro), six weeks in, and I love it. It’s completely different from met or berberine (I usually include a lipo version of berberine) as it targets multiple mechanisms including effectiveness of insulin, activation of leptin receptors, slowed gastric emptying, appetite suppression (which “feels” more like ghrelin suppression and leptin stimulation), lowered systemic inflammation, among other things.
I hesitate to say this, but I kind of “feel” less circulating glucose (haha, I know). But small things like skin discoloration clearing up, shrinking skin tags, elimination of dry skin patches especially on my feet, a few other signals makes me feel like there is less glucose poison coursing through my veins on average. Of course, could be placebo.
For the time being I‘ve substantially reduced my supp stack, including berberine, and keep what I put in my stomach to a bare minimum. I feel somewhat full all day long and swallowing a fist full of supps makes me feel pretty nauseous. This will probably last a few more weeks. No plans to add berberine for now.
