ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Metformin Lowers Testosterone?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="BigTex" data-source="post: 239261" data-attributes="member: 43589"><p>[URL unfurl="true"]https://diabetesjournals.org/care/article/44/4/1059/138596/Rapid-Changes-in-Serum-Testosterone-in-Men-With[/URL]</p><p></p><p><strong>RESULTS</strong></p><p>Total, free, and bioavailable testosterone increased significantly within 5 days (all <em>P</em> < 0.001). After 1 month, compared with the control group, the metformin group had lower total (12.7 vs. 15.3 nmol/L), free (0.20 vs. 0.24 nmol/L), and bioavailable (4.56 vs. 5.31 nmol/L) testosterone (all <em>P</em> < 0.05).</p><p></p><p>So metformin did cause a significant reduction in endogenous testosterone production after 1 month. It is thought that metformin inhibits cytochrome P450-C17a, a key enzyme in the synthesis of steroid hormones. However, the longer-term effect of metformin on testosterone and sexual function remains uncertain. Obviously from your blood testing [USER=12]@mcs[/USER], there was also a significant reduction in total T levels after about 6 months of use. But as you pointed out, being on TRT should keep the levels higher.</p><p></p><p><strong>Observation</strong> - lots of competitive bodybuilders use metformin in the bulking cycle to avoid putting on body fat while consuming extra calories and carbohydrates. It also helps avoid insulin resistance with high doses of HGH. Metformin increases glucose uptake into muscle tissue (incresed sarcoplasmic hypertrophy) while simulating fat loss, improves cholesterol values, and results in an overall improvement in metabolic health.</p></blockquote><p></p>
[QUOTE="BigTex, post: 239261, member: 43589"] [URL unfurl="true"]https://diabetesjournals.org/care/article/44/4/1059/138596/Rapid-Changes-in-Serum-Testosterone-in-Men-With[/URL] [B]RESULTS[/B] Total, free, and bioavailable testosterone increased significantly within 5 days (all [I]P[/I] < 0.001). After 1 month, compared with the control group, the metformin group had lower total (12.7 vs. 15.3 nmol/L), free (0.20 vs. 0.24 nmol/L), and bioavailable (4.56 vs. 5.31 nmol/L) testosterone (all [I]P[/I] < 0.05). So metformin did cause a significant reduction in endogenous testosterone production after 1 month. It is thought that[B] [/B]metformin inhibits cytochrome P450-C17a, a key enzyme in the synthesis of steroid hormones. However, the longer-term effect of metformin on testosterone and sexual function remains uncertain. Obviously from your blood testing [USER=12]@mcs[/USER], there was also a significant reduction in total T levels after about 6 months of use. But as you pointed out, being on TRT should keep the levels higher. [B]Observation[/B] - lots of competitive bodybuilders use metformin in the bulking cycle to avoid putting on body fat while consuming extra calories and carbohydrates. It also helps avoid insulin resistance with high doses of HGH. Metformin increases glucose uptake into muscle tissue (incresed sarcoplasmic hypertrophy) while simulating fat loss, improves cholesterol values, and results in an overall improvement in metabolic health. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Metformin Lowers Testosterone?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top