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Metformin Decreases Aerobic Capacity, Muscle Mass and Testosterone
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<blockquote data-quote="BigTex" data-source="post: 229551" data-attributes="member: 43589"><p>I will add this interesting meta analysis on metformin and IGF-1 levels:</p><p></p><p>Yang X, Kord-Varkaneh H, Talaei S, Clark CCT, Zanghelini F, Tan SC, Zarezadeh M, Mousavi SM, Rahmani J, Zhang Y. <strong>The influence of metformin on IGF-1 levels in humans: A systematic review and meta-analysis.</strong> Pharmacol Res. 2020 Jan;151:104588. doi: 10.1016/j.phrs.2019.104588. Epub 2019 Dec 6. PMID: 31816435.</p><p></p><h2>Abstract</h2><p><strong>Background: </strong>A meta-analysis is needed to comprehensively consolidate findings from the influence of metformin on IGF-1 levels. The present study was conducted with the objective to accurately evaluate the influence of metformin intake on IGF-1 levels via a meta-analysis of randomized controlled trials.</p><p><strong>Methods: </strong>A comprehensive systematic search was carried out in PubMed/MEDLINE, Web of Science, SCOPUS and Embase from inception until June 2019. Weighted mean difference (WMD) with the 95 % CI were applied for estimating the effects of metformin on serum IGF-1 levels.</p><p><strong>Results: </strong>11 studies involving a total of 569 individuals reported changes in IGF-1 plasma concentrations as an outcome measure. Pooled results demonstrated an overall non-significant decline in IGF-1 following metformin intake (WMD: -8.292 ng/ml, 95 % CI: -20.248, 3.664, p = 0.174) with heterogeneity among (p = 0.000,I2 = 87.1 %). The subgroup analyses displayed that intervention duration <12 weeks on children (WMD:-55.402 ng/ml, 95 % CI: -79.845, -30.960, I2 = 0.0 %) significantly reduced IGF-1. Moreover, in age 18 < years older metformin intake (WMD: 15.125 ng/ml, 95 % CI: 5.522, 24.729, I2 = 92.5 %) significantly increased IGF-1 than 18 ≤ years older (WMD:-1.038 ng/ml, 95 % CI: -3.578,1.502,I2 = 78.0 %). Following dose-response evaluation, metformin intake reduced IGF-1 (coefficient for dose-response analysis= -13.14, P = 0.041 and coefficient for liner analysis= -0.066, P = 0.038) significantly based on treatment duration.</p><p><strong>Conclusion: </strong>We found in children, intervention duration <12 weeks yielded significant reductions in IGF-1, whilst paradoxically, in<strong> participants >18 years old, metformin intake significantly increased IGF-1. </strong>We suggest that caution be taken when interpreting the findings of this review, particularly given the discordant supplementation practices between children and adults.</p></blockquote><p></p>
[QUOTE="BigTex, post: 229551, member: 43589"] I will add this interesting meta analysis on metformin and IGF-1 levels: Yang X, Kord-Varkaneh H, Talaei S, Clark CCT, Zanghelini F, Tan SC, Zarezadeh M, Mousavi SM, Rahmani J, Zhang Y. [B]The influence of metformin on IGF-1 levels in humans: A systematic review and meta-analysis.[/B] Pharmacol Res. 2020 Jan;151:104588. doi: 10.1016/j.phrs.2019.104588. Epub 2019 Dec 6. PMID: 31816435. [HEADING=1]Abstract[/HEADING] [B]Background: [/B]A meta-analysis is needed to comprehensively consolidate findings from the influence of metformin on IGF-1 levels. The present study was conducted with the objective to accurately evaluate the influence of metformin intake on IGF-1 levels via a meta-analysis of randomized controlled trials. [B]Methods: [/B]A comprehensive systematic search was carried out in PubMed/MEDLINE, Web of Science, SCOPUS and Embase from inception until June 2019. Weighted mean difference (WMD) with the 95 % CI were applied for estimating the effects of metformin on serum IGF-1 levels. [B]Results: [/B]11 studies involving a total of 569 individuals reported changes in IGF-1 plasma concentrations as an outcome measure. Pooled results demonstrated an overall non-significant decline in IGF-1 following metformin intake (WMD: -8.292 ng/ml, 95 % CI: -20.248, 3.664, p = 0.174) with heterogeneity among (p = 0.000,I2 = 87.1 %). The subgroup analyses displayed that intervention duration <12 weeks on children (WMD:-55.402 ng/ml, 95 % CI: -79.845, -30.960, I2 = 0.0 %) significantly reduced IGF-1. Moreover, in age 18 < years older metformin intake (WMD: 15.125 ng/ml, 95 % CI: 5.522, 24.729, I2 = 92.5 %) significantly increased IGF-1 than 18 ≤ years older (WMD:-1.038 ng/ml, 95 % CI: -3.578,1.502,I2 = 78.0 %). Following dose-response evaluation, metformin intake reduced IGF-1 (coefficient for dose-response analysis= -13.14, P = 0.041 and coefficient for liner analysis= -0.066, P = 0.038) significantly based on treatment duration. [B]Conclusion: [/B]We found in children, intervention duration <12 weeks yielded significant reductions in IGF-1, whilst paradoxically, in[B] participants >18 years old, metformin intake significantly increased IGF-1. [/B]We suggest that caution be taken when interpreting the findings of this review, particularly given the discordant supplementation practices between children and adults. [/QUOTE]
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Metformin Decreases Aerobic Capacity, Muscle Mass and Testosterone
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