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General Health & Fitness
Health & Wellness
Metformin Blocks Benefits of Aerobic Exercise on Insulin Sensitivity and VO2 max
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<blockquote data-quote="Ardoc2" data-source="post: 146954" data-attributes="member: 35578"><p>From everything I have read there is still a lot of debate on Metformin's mechanisms of actions, with many experts admitting they don't fully understand the way it works. This excerpt from fda.gov shows some of the ways it works, and in fact lists reduced glucose absorption as one of the benefits?</p><p>Considering the number of people taking Met with little if any side effects I would doubt his safety is a concern?</p><p></p><p>Excerpt from;</p><p><a href="https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&cad=rja&uact=8&ved=2ahUKEwjS3LqOsu7hAhWqwVkKHfMjAkEQFjAAegQIAhAC&url=https%3A%2F%2Fwww.accessdata.fda.gov%2Fdrugsatfda_docs%2Flabel%2F2006%2F021748s002lbl.pdf&usg=AOvVaw3_pMYcsJnshLgdRIYGDa7H" target="_blank">Mechanism of Action Pharmacokinetics - FDAhttps://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021748s002lbl.pdf</a></p><p></p><p>CLINICAL PHARMACOLOGY</p><p><u>Mechanism of Action</u></p><p>Metformin is an antihyperglycemic agent, which improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Its pharmacologic mechanisms of action are different from other classes of oral antihyperglycemic agents. <em><u>Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization</u></em><u>.</u></p></blockquote><p></p>
[QUOTE="Ardoc2, post: 146954, member: 35578"] From everything I have read there is still a lot of debate on Metformin's mechanisms of actions, with many experts admitting they don't fully understand the way it works. This excerpt from fda.gov shows some of the ways it works, and in fact lists reduced glucose absorption as one of the benefits? Considering the number of people taking Met with little if any side effects I would doubt his safety is a concern? Excerpt from; [URL='https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&cad=rja&uact=8&ved=2ahUKEwjS3LqOsu7hAhWqwVkKHfMjAkEQFjAAegQIAhAC&url=https%3A%2F%2Fwww.accessdata.fda.gov%2Fdrugsatfda_docs%2Flabel%2F2006%2F021748s002lbl.pdf&usg=AOvVaw3_pMYcsJnshLgdRIYGDa7H']Mechanism of Action Pharmacokinetics - FDAhttps://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021748s002lbl.pdf[/URL] CLINICAL PHARMACOLOGY [U]Mechanism of Action[/U] Metformin is an antihyperglycemic agent, which improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Its pharmacologic mechanisms of action are different from other classes of oral antihyperglycemic agents. [I][U]Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization[/U][/I][U].[/U] [/QUOTE]
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General Health & Fitness
Health & Wellness
Metformin Blocks Benefits of Aerobic Exercise on Insulin Sensitivity and VO2 max
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