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General Health & Fitness
Health & Wellness
Metformin Blocks Benefits of Aerobic Exercise on Insulin Sensitivity and VO2 max
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<blockquote data-quote="thirdstone" data-source="post: 146797" data-attributes="member: 25446"><p>This is a bad thing. </p><p></p><p>Mitochondria are the organelles in your cells which convert glucose and oxygen to ATP. ATP is the actual molecule which cells, and especially in this case muscle cells, use directly for energy. Glucose goes into your muscle cells, mitochondria convert it to ATP, the ATP goes to the muscle fibers and that's what makes them go. This can occur aerobicly (with oxygen) or anaerobicly (without oxygen). Hence why exercise is either aerobic or not. The more aerobic exercise you do the mitochondria adapt by building more of the proteins and such that do the conversion, or in other words they become more efficient at converting glucose to ATP, which gives you greater endurance and you become more fit. </p><p></p><p>This is saying that metformin interferes with the adaptation or improvement in your aerobic ability on a cellular level. Sounds to me like it's not horrible, just that you would likely adapt more slowly or make slower progress in your fitness goals while taking it.</p><p></p><p>For me personally though, that's a deal breaker for metformin and I guess I'm going to stop taking it.</p></blockquote><p></p>
[QUOTE="thirdstone, post: 146797, member: 25446"] This is a bad thing. Mitochondria are the organelles in your cells which convert glucose and oxygen to ATP. ATP is the actual molecule which cells, and especially in this case muscle cells, use directly for energy. Glucose goes into your muscle cells, mitochondria convert it to ATP, the ATP goes to the muscle fibers and that's what makes them go. This can occur aerobicly (with oxygen) or anaerobicly (without oxygen). Hence why exercise is either aerobic or not. The more aerobic exercise you do the mitochondria adapt by building more of the proteins and such that do the conversion, or in other words they become more efficient at converting glucose to ATP, which gives you greater endurance and you become more fit. This is saying that metformin interferes with the adaptation or improvement in your aerobic ability on a cellular level. Sounds to me like it's not horrible, just that you would likely adapt more slowly or make slower progress in your fitness goals while taking it. For me personally though, that's a deal breaker for metformin and I guess I'm going to stop taking it. [/QUOTE]
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General Health & Fitness
Health & Wellness
Metformin Blocks Benefits of Aerobic Exercise on Insulin Sensitivity and VO2 max
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