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Metformin Blocks Benefits of Aerobic Exercise on Insulin Sensitivity and VO2 max
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<blockquote data-quote="dnfuss" data-source="post: 143405" data-attributes="member: 15487"><p>It can be ordered through All Day Chemist or Reliable Rx Pharmacy in India (some say without prescription). It's a perfectly good generic. Very cheap.</p><p></p><p></p><p></p><p>That was not the question. The statement was that metformin is most effective when combined with a low-carb diet. That is, it generally won't bring the blood sugars of someone who is pre-diabetic or diabetic into the completely normal range if they continue on the Standard American Diet.</p><p></p><p></p><p></p><p>They are different. There are oral agents, such as Acarbose, that actually block (prevent the digestion of) a (limited) amount of complex carbs when taken correctly. But (1) they don't have the same effect on simple sugars, (2) they are quite difficult to time and dose correctly and (3) they have their own side effects. Such blocking of carbohydrate digestion is not a known mechanism of action of metformin.</p><p></p><p></p><p></p><p>Metformin much more profoundly affects the first two pathways than the third. That's why it is so much more effective in conjunction with a low-carbohydrate diet.</p><p></p><p></p><p></p><p>It wouldn't be surprising if blood sugar spikes after a high-carb meal when on metformin were lower than they might be without metformin but still higher than normal levels (and therefore still damaging). But good luck.</p></blockquote><p></p>
[QUOTE="dnfuss, post: 143405, member: 15487"] It can be ordered through All Day Chemist or Reliable Rx Pharmacy in India (some say without prescription). It's a perfectly good generic. Very cheap. That was not the question. The statement was that metformin is most effective when combined with a low-carb diet. That is, it generally won't bring the blood sugars of someone who is pre-diabetic or diabetic into the completely normal range if they continue on the Standard American Diet. They are different. There are oral agents, such as Acarbose, that actually block (prevent the digestion of) a (limited) amount of complex carbs when taken correctly. But (1) they don't have the same effect on simple sugars, (2) they are quite difficult to time and dose correctly and (3) they have their own side effects. Such blocking of carbohydrate digestion is not a known mechanism of action of metformin. Metformin much more profoundly affects the first two pathways than the third. That's why it is so much more effective in conjunction with a low-carbohydrate diet. It wouldn't be surprising if blood sugar spikes after a high-carb meal when on metformin were lower than they might be without metformin but still higher than normal levels (and therefore still damaging). But good luck. [/QUOTE]
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General Health & Fitness
Health & Wellness
Metformin Blocks Benefits of Aerobic Exercise on Insulin Sensitivity and VO2 max
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