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General Health & Fitness
Health & Wellness
Metformin Blocks Benefits of Aerobic Exercise on Insulin Sensitivity and VO2 max
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<blockquote data-quote="testiculus" data-source="post: 143356" data-attributes="member: 17128"><p>Just read the full study text. Unfortunately it is difficult to draw any conclusions due to the study design. It wasn't conducted as a cross-over trial. There is a huge amount of variability in individual response to aerobic exercise. Some people are non-responders and others are hyper-responders. No attempt was made to account for this and therefore it completely invalidates the randomization of the trial. In addition to that, they made another bad decision in how they conducted the exercise. The VO2max testing was done on a stationary bike, but the study participants were allow to select the type of exercise they performed over the course of the study (treadmill, stationary bike, or elliptical). Since VO2max testing is specific to the type of exercise performed, any participant that did their exercise on the stationary bike would have seen more improvement in the subsequent VO2max test than those if they had used the other modalities. The paper did not report the breakdown of exercise modality between the two groups. More participants choosing the stationary bike in one group would also invalidate the results. So the only conclusion is that for some people metformin may not work well when combined with exercise, while for others it will work just fine when combined with exercise.</p></blockquote><p></p>
[QUOTE="testiculus, post: 143356, member: 17128"] Just read the full study text. Unfortunately it is difficult to draw any conclusions due to the study design. It wasn't conducted as a cross-over trial. There is a huge amount of variability in individual response to aerobic exercise. Some people are non-responders and others are hyper-responders. No attempt was made to account for this and therefore it completely invalidates the randomization of the trial. In addition to that, they made another bad decision in how they conducted the exercise. The VO2max testing was done on a stationary bike, but the study participants were allow to select the type of exercise they performed over the course of the study (treadmill, stationary bike, or elliptical). Since VO2max testing is specific to the type of exercise performed, any participant that did their exercise on the stationary bike would have seen more improvement in the subsequent VO2max test than those if they had used the other modalities. The paper did not report the breakdown of exercise modality between the two groups. More participants choosing the stationary bike in one group would also invalidate the results. So the only conclusion is that for some people metformin may not work well when combined with exercise, while for others it will work just fine when combined with exercise. [/QUOTE]
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General Health & Fitness
Health & Wellness
Metformin Blocks Benefits of Aerobic Exercise on Insulin Sensitivity and VO2 max
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