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Health & Wellness
Metformin Blocks Benefits of Aerobic Exercise on Insulin Sensitivity and VO2 max
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<blockquote data-quote="DragonBits" data-source="post: 143186" data-attributes="member: 18023"><p>I was going to try CoffeeGenic® Green Coffee Extract, 400 mg, which has chlorogenic acid 200 mg.</p><p></p><p>Chlorogenic acid inhibits the glucose-6-phosphatase enzyme that stimulates glycogenolysis and gluconeogenesis.</p><p></p><p>In people as they age, balancing mechanism of your liver's glycogenolysis and gluconeogenesis may become impaired. Normally the liver would not release glucose after a meal, but as you age sometimes your liver can dump glucose in response to a heavy meal.</p><p></p><p>At the core of pathologic glycogenolysis (release of stored blood sugar) and gluconeogenesis (synthesis of new sugar) is the enzyme <strong><em>glucose-6-phosphatase</em></strong>. <strong>Heavy meals can activate this enzyme</strong>, which in turn tells your liver to release its sugar stores and helps it to make more sugar, despite the flood of glucose from the meal you just finished.</p><p></p><p>LEF had an interesting article on this.</p><p></p><p><a href="https://www.lifeextension.com/Magazine/2012/2/Suppress-Deadly-After-Meal-Blood-Sugar-Surges/Page-01" target="_blank">Suppress Blood Sugar Surges | Life Extension Magazine</a></p><p></p><p>Not sure this supplement (chlorogenic acid) will work, and I suspect I will resume taking metformin, but if this works it might be good to take them both.</p><p></p><p>I have felt for a long time that a heavy meal affects me more than most people.</p></blockquote><p></p>
[QUOTE="DragonBits, post: 143186, member: 18023"] I was going to try CoffeeGenic® Green Coffee Extract, 400 mg, which has chlorogenic acid 200 mg. Chlorogenic acid inhibits the glucose-6-phosphatase enzyme that stimulates glycogenolysis and gluconeogenesis. In people as they age, balancing mechanism of your liver's glycogenolysis and gluconeogenesis may become impaired. Normally the liver would not release glucose after a meal, but as you age sometimes your liver can dump glucose in response to a heavy meal. At the core of pathologic glycogenolysis (release of stored blood sugar) and gluconeogenesis (synthesis of new sugar) is the enzyme [B][I]glucose-6-phosphatase[/I][/B]. [B]Heavy meals can activate this enzyme[/B], which in turn tells your liver to release its sugar stores and helps it to make more sugar, despite the flood of glucose from the meal you just finished. LEF had an interesting article on this. [URL="https://www.lifeextension.com/Magazine/2012/2/Suppress-Deadly-After-Meal-Blood-Sugar-Surges/Page-01"]Suppress Blood Sugar Surges | Life Extension Magazine[/URL] Not sure this supplement (chlorogenic acid) will work, and I suspect I will resume taking metformin, but if this works it might be good to take them both. I have felt for a long time that a heavy meal affects me more than most people. [/QUOTE]
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General Health & Fitness
Health & Wellness
Metformin Blocks Benefits of Aerobic Exercise on Insulin Sensitivity and VO2 max
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