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Health & Wellness
Metformin Blocks Benefits of Aerobic Exercise on Insulin Sensitivity and VO2 max
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<blockquote data-quote="DragonBits" data-source="post: 141694" data-attributes="member: 18023"><p>The tone was negative, but it's not a huge negative, limiting VO2 max, causing fatigue in some people which probably isn't noticed unless you work out with intensity.</p><p></p><p>It's really all about the anti-aging use of Metformin for people without impaired insulin control / disabilities. <strong>SHOULD healthy people take Metformin</strong>?</p><p></p><p>Clearly the benefits of Metformin for those with elevated blood glucose outweighs the problem that Metformin "inhibits mitochondrial adaptations to aerobic exercise training in older adults".</p><p></p><p>I had been taking 2x 500 ER metformin, my A1C was 5.8, in a month it went to 5.6, four days ago I measured it at 5.2. BUT I changed my diet and lost 18 lbs, so how much Met helped is debatable. It seemed to reduce my appetite for the first 20 lbs of weight loss, but now at least my appetite has returned to normal.</p><p></p><p>After the test, I quit taking Metformin, which is 4 days ago, I wanted to see how it affected my treadmill cardio and appetite control. So far my BG taken with a meter is OK, my cardio seems better. But I think the better test will be in a month to check A1C and then start Metformin again.</p><p></p><p>So I am certain with diet and exercise I can keep my A1C at 5.2, but not sure about how hard it will be to do that.</p><p></p><p>Long post, but IMO it's a little complicated.</p></blockquote><p></p>
[QUOTE="DragonBits, post: 141694, member: 18023"] The tone was negative, but it's not a huge negative, limiting VO2 max, causing fatigue in some people which probably isn't noticed unless you work out with intensity. It's really all about the anti-aging use of Metformin for people without impaired insulin control / disabilities. [B]SHOULD healthy people take Metformin[/B]? Clearly the benefits of Metformin for those with elevated blood glucose outweighs the problem that Metformin "inhibits mitochondrial adaptations to aerobic exercise training in older adults". I had been taking 2x 500 ER metformin, my A1C was 5.8, in a month it went to 5.6, four days ago I measured it at 5.2. BUT I changed my diet and lost 18 lbs, so how much Met helped is debatable. It seemed to reduce my appetite for the first 20 lbs of weight loss, but now at least my appetite has returned to normal. After the test, I quit taking Metformin, which is 4 days ago, I wanted to see how it affected my treadmill cardio and appetite control. So far my BG taken with a meter is OK, my cardio seems better. But I think the better test will be in a month to check A1C and then start Metformin again. So I am certain with diet and exercise I can keep my A1C at 5.2, but not sure about how hard it will be to do that. Long post, but IMO it's a little complicated. [/QUOTE]
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General Health & Fitness
Health & Wellness
Metformin Blocks Benefits of Aerobic Exercise on Insulin Sensitivity and VO2 max
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