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Metformin Blocks Benefits of Aerobic Exercise on Insulin Sensitivity and VO2 max
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<blockquote data-quote="DragonBits" data-source="post: 141455" data-attributes="member: 18023"><p>Can someone help me with the math on this NIH example? It’s a typical way for them to express amounts, but I never really felt sure I understood it.</p><p></p><p><span style="color: rgb(184, 49, 47)">Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice. </span></p><p><span style="color: rgb(184, 49, 47)"></span></p><p><span style="color: rgb(184, 49, 47)">The effects of Leu (24 g/kg diet)+Met (0.05-0.5 g/kg diet) combinations were compared to standard therapeutic Met (1.5 g/kg diet; ~300 mg/kg BW) on glycemic control in high fat diet induced insulin resistant mice for 6 weeks.</span></p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/25858853" target="_blank">Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice. - PubMed - NCBI</a></p><p></p><p>I am never sure I get the amounts that subjects are fed. (In this case, mice).</p><p></p><p>As I read this, the standard therapeutic Met 300mg/kg BW would mean for a human at 64kg, they would need 19.2 Grams of Met to equal this, which is way above the max dosage of 2250 mg of Met. BUT if I look at MET = 1.5 g/kg diet and assume humans eat ~2.5Kkgs day, then it’s more reasonable 3.75 grams. Still way higher than the max recommended dose of 2550 mg a day for humans, more reasonable yet not in agreement with 300 mg/Kg BW quoted.</p><p></p><p>And Leucine (Leu), it doesn’t say how much per BW, but humans typically eat ~2.5 kg of cooked food a day, which would translate to 60 grams of Leucine.</p><p></p><p>(It could be that mice need a lot higher dose of MET to be therapeutic, and that mice eat a lot more kg of food (5x)per kg of BW than a human. But is that a correct way to interpret this?)</p><p></p><p>It's typical for me in these type of abstracts, I get that adding Leucine to your diet enhances the effects of Metformin, but I never get the actual amounts used in the study.</p><p></p><p>Am I correct or can someone provide a way of how to convert this to how much for a human that weighs 64kg or make sense of it for me?</p></blockquote><p></p>
[QUOTE="DragonBits, post: 141455, member: 18023"] Can someone help me with the math on this NIH example? It’s a typical way for them to express amounts, but I never really felt sure I understood it. [COLOR=rgb(184, 49, 47)]Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice. The effects of Leu (24 g/kg diet)+Met (0.05-0.5 g/kg diet) combinations were compared to standard therapeutic Met (1.5 g/kg diet; ~300 mg/kg BW) on glycemic control in high fat diet induced insulin resistant mice for 6 weeks.[/COLOR] [URL="https://www.ncbi.nlm.nih.gov/pubmed/25858853"]Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice. - PubMed - NCBI[/URL] I am never sure I get the amounts that subjects are fed. (In this case, mice). As I read this, the standard therapeutic Met 300mg/kg BW would mean for a human at 64kg, they would need 19.2 Grams of Met to equal this, which is way above the max dosage of 2250 mg of Met. BUT if I look at MET = 1.5 g/kg diet and assume humans eat ~2.5Kkgs day, then it’s more reasonable 3.75 grams. Still way higher than the max recommended dose of 2550 mg a day for humans, more reasonable yet not in agreement with 300 mg/Kg BW quoted. And Leucine (Leu), it doesn’t say how much per BW, but humans typically eat ~2.5 kg of cooked food a day, which would translate to 60 grams of Leucine. (It could be that mice need a lot higher dose of MET to be therapeutic, and that mice eat a lot more kg of food (5x)per kg of BW than a human. But is that a correct way to interpret this?) It's typical for me in these type of abstracts, I get that adding Leucine to your diet enhances the effects of Metformin, but I never get the actual amounts used in the study. Am I correct or can someone provide a way of how to convert this to how much for a human that weighs 64kg or make sense of it for me? [/QUOTE]
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Metformin Blocks Benefits of Aerobic Exercise on Insulin Sensitivity and VO2 max
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