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Hey Nelson,

These are also my concerns are with metformin. Meformin inhibits complex I of the mitochondrial respiratory chain. The consequences of this action is a loss of ATP production, increases in ATP and AMP which further activates AMP kinase. These actions don’t appear to cause mitochondrial toxicity but more research is needed.

I’ve been on the fence on metformin for years. At this time I feel the risks outweigh the benefits but I can’t be sure.

I would love to hear your current option on taking metformin? Do you believe the benefits outweigh the risks? What are your thoughts on metformin and mitochondria?