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Metformin and Testosterone
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<blockquote data-quote="Nelson Vergel" data-source="post: 56294" data-attributes="member: 3"><p>This one is also interesting for us on this site:</p><p></p><p><strong> <a href="https://www.excelmale.com/forum/showthread.php?5714-Testosterone-Replacement-Enhances-the-Effects-of-Metformin-on-Lipids-and-Inflammation" target="_blank">Testosterone Replacement Enhances the Effects of Metformin on Lipids and Inflammation</a></strong></p><p><strong></strong></p><p><strong></strong>"<span style="color: #333333"> After 12 weeks of metformin treatment (1.7&#8201;g daily), the participants were allocated to one of 2 groups treated for the following 12 weeks with oral testosterone undecanoate (120&#8201;mg daily, n=15) or not receiving androgen therapy (n=15)"</span></p><p></p><p></p><p>This one contradicts the one we are discussing:</p><p></p><p><strong><a href="https://www.excelmale.com/forum/showthread.php?6522-Metformin-improves-semen-and-testosterone-in-men-with-metabolic-syndrome" target="_blank">Metformin improves semen and testosterone in men with metabolic syndrome</a></strong></p><p><strong></strong></p><p><strong></strong>This is the protocol used : </p><p>"<span style="color: #333333">The protocol for the study was approved by the internal ethics committee. After we had obtained the patients' written informed consent, they received metformin for a period of 6 months. The dose was gradually increased from an initial daily dose of 850 mg/day (every lunch) for the first week, to 850 mg twice a day (every lunch and dinner) in the second week, to 850 mg three times a day (every breakfast, lunch, and dinner) for the rest of the treatment period."</span></p><p></p><p></p><p>And one related to TSH</p><p></p><p><strong><a href="https://www.excelmale.com/forum/showthread.php?6521-Effect-of-metformin-on-thyroid-stimulating-hormone-and-thyroid-volume-in-patients-with-prediabetes" target="_blank">Effect of metformin on thyroid stimulating hormone and thyroid volume in patients with prediabetes</a></strong></p><p></p><p>"...<span style="color: #000000">we prescribed 500 mg of either metformin or placebo, with weekly increment of 1 tablet (500 mg) consequently to achieve the ultimate dose of 1500 mg in participants whom tolerate this dose-escalation protocol."</span></p><p><span style="color: #000000"></span></p><p><span style="color: #000000"></span>_________________________________</p><p></p><p>I take 500 mg twice per day. I may go up in dose soon (with the hope of more fat loss and no GI problems)</p><p><span style="color: #333333"></span></p><p><span style="color: #333333"></span></p><p><span style="color: #333333">I have lost weight and do not feel as pumped since starting Metformin three months ago. I will see if I stay on it or not in the long term.</span></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 56294, member: 3"] This one is also interesting for us on this site: [B] [URL="https://www.excelmale.com/forum/showthread.php?5714-Testosterone-Replacement-Enhances-the-Effects-of-Metformin-on-Lipids-and-Inflammation"]Testosterone Replacement Enhances the Effects of Metformin on Lipids and Inflammation[/URL] [/B]"[COLOR=#333333] After 12 weeks of metformin treatment (1.7 g daily), the participants were allocated to one of 2 groups treated for the following 12 weeks with oral testosterone undecanoate (120 mg daily, n=15) or not receiving androgen therapy (n=15)"[/COLOR] This one contradicts the one we are discussing: [B][URL="https://www.excelmale.com/forum/showthread.php?6522-Metformin-improves-semen-and-testosterone-in-men-with-metabolic-syndrome"]Metformin improves semen and testosterone in men with metabolic syndrome[/URL] [/B]This is the protocol used : "[COLOR=#333333][FONT='inherit']The protocol for the study was approved by the internal ethics committee. After we had obtained the patients' written informed consent, they received metformin for a period of 6 months. The dose was gradually increased from an initial daily dose of 850 mg/day (every lunch) for the first week, to 850 mg twice a day (every lunch and dinner) in the second week, to 850 mg three times a day (every breakfast, lunch, and dinner) for the rest of the treatment period."[/FONT][/COLOR] And one related to TSH [B][URL="https://www.excelmale.com/forum/showthread.php?6521-Effect-of-metformin-on-thyroid-stimulating-hormone-and-thyroid-volume-in-patients-with-prediabetes"]Effect of metformin on thyroid stimulating hormone and thyroid volume in patients with prediabetes[/URL][/B] "...[COLOR=#000000][FONT='inherit']we prescribed 500 mg of either metformin or placebo, with weekly increment of 1 tablet (500 mg) consequently to achieve the ultimate dose of 1500 mg in participants whom tolerate this dose-escalation protocol." [/FONT][/COLOR]_________________________________ I take 500 mg twice per day. I may go up in dose soon (with the hope of more fat loss and no GI problems) [COLOR=#333333] I have lost weight and do not feel as pumped since starting Metformin three months ago. I will see if I stay on it or not in the long term.[/COLOR] [/QUOTE]
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