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Metformin has shown an ability to decrease methylation by interfering with B12 absorption with long-term use Hyperhomocysteinemia, deep vein thrombosis and vitamin B12 deficiency in a metformin-treated diabetic patient.  - PubMed - NCBI. We are just now realizing how important methylation is the more we understand genetics. It would be important to take B12 if you're going to use metformin.