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Metformin and B12 deficiency
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<blockquote data-quote="Will Brink" data-source="post: 81676" data-attributes="member: 2074"><p>FYI, latest study does not find Metformin associated with B12 deficiency, but it should be noted B12 deficiencies are not uncommon so worth</p><p>screening for regardless of metformin use in my view. </p><p></p><p></p><p>Am J Med Sci. 2017 Aug;354(2):165-171. doi: 10.1016/j.amjms.2017.04.010.</p><p>Epub 2017 Jul 8.</p><p></p><p>Metformin Use and Vitamin B12 Deficiency: Untangling the Association.</p><p></p><p>Abstract</p><p>BACKGROUND:</p><p></p><p>Current evidence linking vitamin B12 deficiency with metformin use is</p><p>inconsistent. Hence, there is uncertainty regarding the diagnostic</p><p>approach in this scenario. Furthermore, this possible association has not</p><p>been studied in the complete spectrum of patients with diabetes.</p><p>MATERIALS AND METHODS:</p><p></p><p>We conducted a cross-sectional, controlled study with the objective of</p><p>assessing differences in serum vitamin B12 levels among patients with and</p><p>without diabetes with different metformin-treatment regimens. A total of</p><p>150 participants were recruited: patients with diabetes (group 1:</p><p>metformin alone &#8805;850mg/day, group 2: patients with type 2 diabetes naive</p><p>to treatment and group 3: metformin &#8805;850mg/day, in addition to any other</p><p>oral glucose lowering agent or insulin, or both) and without diabetes</p><p>(group 4: polycystic ovary syndrome or group 5: healthy individuals).</p><p>Serum vitamin B12, folate levels and complete blood counts were obtained</p><p>for the entire population. Methylmalonic acid and homocysteine were</p><p>obtained for patients when vitamin B12 levels were found to be borderline</p><p>or low.</p><p></p><p>RESULTS:</p><p></p><p>When patients with or without diabetes were compared, no significant</p><p>difference was found in relation to their vitamin B12 levels (517.62</p><p>versus 433.83; P = 0.072). No difference in vitamin B12 levels was found</p><p>among participants with metformin use and metformin naive participants</p><p>(503.4 versus 462.3; P = 0.380).</p><p></p><p>CONCLUSIONS:</p><p></p><p>Irrespective of metformin use, no significant difference in the serum</p><p>levels of vitamin B12 was observed, both in patients with and without</p><p>diabetes. In the light of the body of evidence and the results of this</p><p>study, a universal recommendation for vitamin B12 deficiency screening</p><p>cannot be made.</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/28864375" target="_blank">https://www.ncbi.nlm.nih.gov/pubmed/28864375</a></p></blockquote><p></p>
[QUOTE="Will Brink, post: 81676, member: 2074"] FYI, latest study does not find Metformin associated with B12 deficiency, but it should be noted B12 deficiencies are not uncommon so worth screening for regardless of metformin use in my view. Am J Med Sci. 2017 Aug;354(2):165-171. doi: 10.1016/j.amjms.2017.04.010. Epub 2017 Jul 8. Metformin Use and Vitamin B12 Deficiency: Untangling the Association. Abstract BACKGROUND: Current evidence linking vitamin B12 deficiency with metformin use is inconsistent. Hence, there is uncertainty regarding the diagnostic approach in this scenario. Furthermore, this possible association has not been studied in the complete spectrum of patients with diabetes. MATERIALS AND METHODS: We conducted a cross-sectional, controlled study with the objective of assessing differences in serum vitamin B12 levels among patients with and without diabetes with different metformin-treatment regimens. A total of 150 participants were recruited: patients with diabetes (group 1: metformin alone ≥850mg/day, group 2: patients with type 2 diabetes naive to treatment and group 3: metformin ≥850mg/day, in addition to any other oral glucose lowering agent or insulin, or both) and without diabetes (group 4: polycystic ovary syndrome or group 5: healthy individuals). Serum vitamin B12, folate levels and complete blood counts were obtained for the entire population. Methylmalonic acid and homocysteine were obtained for patients when vitamin B12 levels were found to be borderline or low. RESULTS: When patients with or without diabetes were compared, no significant difference was found in relation to their vitamin B12 levels (517.62 versus 433.83; P = 0.072). No difference in vitamin B12 levels was found among participants with metformin use and metformin naive participants (503.4 versus 462.3; P = 0.380). CONCLUSIONS: Irrespective of metformin use, no significant difference in the serum levels of vitamin B12 was observed, both in patients with and without diabetes. In the light of the body of evidence and the results of this study, a universal recommendation for vitamin B12 deficiency screening cannot be made. [URL]https://www.ncbi.nlm.nih.gov/pubmed/28864375[/URL] [/QUOTE]
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Metformin and B12 deficiency
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