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General Health & Fitness
Health & Wellness
Metabolic flexibility and its impact on health and disease
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<blockquote data-quote="madman" data-source="post: 194159" data-attributes="member: 13851"><p><em><strong>*</strong></em><u><em><strong>Disruption in metabolic flexibility is most commonly caused by excess food intake and sedentary lifestyle, contributing to mitochondrial dysfunction characterized by inefficient nutrient sensing and ineffective substrate switching deemed as “Metabolic inflexibility</strong></em></u><em><strong>.” </strong>This condition alters metabolic and non-metabolic pathways leading to the development of IR and β-cell dysfunction. </em><strong><em><u>All these effects induce cellular events, including increase oxidative stress and inflammation, endothelial dysfunction, production and accumulation of advanced glycation end products, ectopic fat accumulation resulting in dyslipidemia, hypertension, and micro-and macro-vascular complications</u>.</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 194159, member: 13851"] [I][B]*[/B][/I][U][I][B]Disruption in metabolic flexibility is most commonly caused by excess food intake and sedentary lifestyle, contributing to mitochondrial dysfunction characterized by inefficient nutrient sensing and ineffective substrate switching deemed as “Metabolic inflexibility[/B][/I][/U][I][B].” [/B]This condition alters metabolic and non-metabolic pathways leading to the development of IR and β-cell dysfunction. [/I][B][I][U]All these effects induce cellular events, including increase oxidative stress and inflammation, endothelial dysfunction, production and accumulation of advanced glycation end products, ectopic fat accumulation resulting in dyslipidemia, hypertension, and micro-and macro-vascular complications[/U].[/I][/B] [/QUOTE]
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General Health & Fitness
Health & Wellness
Metabolic flexibility and its impact on health and disease
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