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Mental Sexual Desire increase on TRT with Mucuna?
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<blockquote data-quote="Nelson Vergel" data-source="post: 125592" data-attributes="member: 3"><p>Real Mucuna increases dopamine slightly. But getting the real stuff is important. Dopamine is associated with libido and mood. Mucuna pruriens is the best known natural source of L-dopa, the gold standard for treatment of Parkinsonism.</p><p></p><p>I tried it but saw no effect. Not sure if I got the real stuff or if it is all BS.</p><p></p><p>I do not have full access of this paper:</p><p></p><p>The Journal of Alternative and Complementary MedicineVol. 24, No. 2</p><p></p><p></p><p><strong><span style="font-size: 18px">Levodopa Content in Commercial Mucuna pruriens Products Using High-Performance Liquid Chromatography with Fluorescence Detection</span></strong></p><p></p><p></p><p><span style="font-size: 22px"><strong>Abstract</strong></span></p><p><strong><em>Objectives:</em></strong><em>Mucuna pruriens</em> (MP) seeds contain levodopa (up to 2% by weight) and have been used in traditional Indian medicine to treat an illness named “Kampavata,” now understood to be Parkinson's disease (PD). Studies have shown MP to be beneficial, and even superior, to levodopa alone in treating PD symptoms. Commercial products containing MP are readily available from online and retail sources to patients and physicians. Products often contain extracts of MP seeds, with significantly higher levodopa content than the seeds. However, MP products have limited regulatory controls with respect to quality and content of active ingredient. The aim of this study was to apply a quantitative method to determine levodopa content in readily available MP products that might be used by patients or in research studies.</p><p><strong><em>Design:</em></strong> Levodopa present in six commercial MP products was quantified by solvent extraction followed by reversed-phase high-performance liquid chromatography (HPLC) coupled to fluorescence detection (FD). Certificates of analysis (COA) were obtained, from manufacturers of MP products, to assess the existence and implementation of specifications for levodopa content.</p><p><strong><em>Results:</em> HPLC-FD analysis revealed that the levodopa content of the six commercial MP products varied from 6% to 141% of individual label claims. No product contained levodopa within normal pharmacopeial limits of 90%–110% label claim. </strong>The maximum daily dose of levodopa delivered by the products varied from 14.4 to 720 mg/day. COAs were inconsistent in specifications for and verification of levodopa content.</p><p><strong><em>Conclusions:</em></strong> The commercial products tested varied widely in levodopa content, sometimes deviating widely from the label claim. These deficiencies could impact efficacy and safety of MP products used by PD patients and compromise the results of scientific studies on MP products. The HPLC-FD method described in this study could be utilized by both manufacturers and scientific researchers to verify levodopa content of MP products.</p><p></p><p></p><p></p><p>I am also looking into GPC Choline.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 125592, member: 3"] Real Mucuna increases dopamine slightly. But getting the real stuff is important. Dopamine is associated with libido and mood. Mucuna pruriens is the best known natural source of L-dopa, the gold standard for treatment of Parkinsonism. I tried it but saw no effect. Not sure if I got the real stuff or if it is all BS. I do not have full access of this paper: The Journal of Alternative and Complementary MedicineVol. 24, No. 2 [B][SIZE=18px]Levodopa Content in Commercial Mucuna pruriens Products Using High-Performance Liquid Chromatography with Fluorescence Detection[/SIZE][/B] [SIZE=22px][B]Abstract[/B][/SIZE] [B][I]Objectives:[/I][/B][I]Mucuna pruriens[/I] (MP) seeds contain levodopa (up to 2% by weight) and have been used in traditional Indian medicine to treat an illness named “Kampavata,” now understood to be Parkinson's disease (PD). Studies have shown MP to be beneficial, and even superior, to levodopa alone in treating PD symptoms. Commercial products containing MP are readily available from online and retail sources to patients and physicians. Products often contain extracts of MP seeds, with significantly higher levodopa content than the seeds. However, MP products have limited regulatory controls with respect to quality and content of active ingredient. The aim of this study was to apply a quantitative method to determine levodopa content in readily available MP products that might be used by patients or in research studies. [B][I]Design:[/I][/B] Levodopa present in six commercial MP products was quantified by solvent extraction followed by reversed-phase high-performance liquid chromatography (HPLC) coupled to fluorescence detection (FD). Certificates of analysis (COA) were obtained, from manufacturers of MP products, to assess the existence and implementation of specifications for levodopa content. [B][I]Results:[/I] HPLC-FD analysis revealed that the levodopa content of the six commercial MP products varied from 6% to 141% of individual label claims. No product contained levodopa within normal pharmacopeial limits of 90%–110% label claim. [/B]The maximum daily dose of levodopa delivered by the products varied from 14.4 to 720 mg/day. COAs were inconsistent in specifications for and verification of levodopa content. [B][I]Conclusions:[/I][/B] The commercial products tested varied widely in levodopa content, sometimes deviating widely from the label claim. These deficiencies could impact efficacy and safety of MP products used by PD patients and compromise the results of scientific studies on MP products. The HPLC-FD method described in this study could be utilized by both manufacturers and scientific researchers to verify levodopa content of MP products. I am also looking into GPC Choline. [/QUOTE]
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