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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Men's Response to Testosterone Depends on their CAG Repeats in Their AR Gene.
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<blockquote data-quote="madman" data-source="post: 178995" data-attributes="member: 13851"><p><strong>The CAG repeat polymorphism within the androgen receptor gene and maleness</strong></p><p></p><p><span style="color: rgb(184, 49, 47)">MICHAEL ZITZMANN and EBERHARD NIESCHLAG</span></p><p><span style="color: rgb(184, 49, 47)">Institute of Reproductive Medicine of the University, Munster, Germany</span></p><p><span style="color: rgb(184, 49, 47)"></span></p><p><span style="color: rgb(184, 49, 47)"></span></p><p><span style="color: rgb(184, 49, 47)"><strong>Figure 1.</strong></span><strong> Display of the X chromosome with the androgen receptor (AR) gene at q11–12. Exon 1 contains a variable number CAG repeats which encodes for a polyglutamine stretch of variable length in the receptor protein. The number of CAG repeats or length of polyglutamine residues is inversely correlated with the transcriptional activity of androgen target genes.</strong></p><p><span style="color: rgb(184, 49, 47)">[ATTACH=full]9778[/ATTACH]</span></p><p><span style="color: rgb(184, 49, 47)"></span></p><p><span style="color: rgb(184, 49, 47)"></span></p><p><span style="color: rgb(184, 49, 47)"></span></p><p><span style="color: rgb(184, 49, 47)"></span></p><p><span style="color: rgb(184, 49, 47)"></span></p><p><span style="color: rgb(184, 49, 47)"><strong>Figure 2. </strong></span><strong>The inverse association between the number of CAG repeats in the AR gene and functionality of the AR protein. <span style="color: rgb(184, 49, 47)">Longer CAG tracts result in lower transcription of target genes and, thus, lower androgenicity. </span>Expansion of the encoded polyglutamine stretch to beyond probably 38 leads to the neuromuscular disorder X-linked spinal bulbar muscular atrophy (XSBMA), a condition in which defective spermatogenesis and undervirilization are observed. </strong><span style="color: rgb(184, 49, 47)"><strong>Conversely, low numbers of CAG repeats are associated with increased androgenicity of susceptible tissues.</strong></span></p><p><strong>[ATTACH=full]9779[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 178995, member: 13851"] [B]The CAG repeat polymorphism within the androgen receptor gene and maleness[/B] [COLOR=rgb(184, 49, 47)]MICHAEL ZITZMANN and EBERHARD NIESCHLAG Institute of Reproductive Medicine of the University, Munster, Germany [B]Figure 1.[/B][/COLOR][B] Display of the X chromosome with the androgen receptor (AR) gene at q11–12. Exon 1 contains a variable number CAG repeats which encodes for a polyglutamine stretch of variable length in the receptor protein. The number of CAG repeats or length of polyglutamine residues is inversely correlated with the transcriptional activity of androgen target genes.[/B] [COLOR=rgb(184, 49, 47)][ATTACH type="full" alt="Screenshot (1448).png"]9778[/ATTACH] [B]Figure 2. [/B][/COLOR][B]The inverse association between the number of CAG repeats in the AR gene and functionality of the AR protein. [COLOR=rgb(184, 49, 47)]Longer CAG tracts result in lower transcription of target genes and, thus, lower androgenicity. [/COLOR]Expansion of the encoded polyglutamine stretch to beyond probably 38 leads to the neuromuscular disorder X-linked spinal bulbar muscular atrophy (XSBMA), a condition in which defective spermatogenesis and undervirilization are observed. [/B][COLOR=rgb(184, 49, 47)][B]Conversely, low numbers of CAG repeats are associated with increased androgenicity of susceptible tissues.[/B][/COLOR] [B][ATTACH type="full" alt="Screenshot (1449).png"]9779[/ATTACH][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Men's Response to Testosterone Depends on their CAG Repeats in Their AR Gene.
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