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Men with high levels of anabolic hormones less likely to develop worsening frailty
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<blockquote data-quote="Nelson Vergel" data-source="post: 76962" data-attributes="member: 3"><p><span style="font-size: 12px"><span style="font-size: 10px"><span style="color: #333333">The researchers found that having higher baseline levels of vitamin D, insulin-like growth factor-1 (IGF-1) and its binding protein 3 (IGFBP3) was associated with a lower risk of worse frailty status four years later. "Vitamin D, besides maintaining bone health, regulates muscle function, and low vitamin D levels are linked to lower muscle mass and strength. IGF-1 affects muscle growth and repair, and its action and levels are modified by its carrier protein IGFBP3," Swiecicka said.</span></span></span></p><p><span style="font-size: 12px"><span style="font-size: 10px"><span style="color: #333333">Also linked to a lower likelihood of frailty status worsening were higher baseline levels of the hormone dehydroepiandrosterone sulfate (DHEA-S), but only in the oldest men. Several potential pathways could link DHEA-S with frailty. Swiecicka said, "DHEA-S may have direct anabolic effect on muscle, and, more recently, its neuroprotective and immune system-modulating effects have been described."</span></span></span></p><p><span style="font-size: 12px"></span><span style="color: #000000"></span></p><p><span style="color: #000000"></span></p><p><span style="color: #000000">http://www.endocrine.org/news-room/current-press-releases/higher-anabolic-hormone-levels-predict-lower-risk-of-worsening-frailty-in-men </span></p><p><span style="color: #000000"></span></p><p><span style="color: #000000"></span></p><p><span style="color: #000000"></span></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 76962, member: 3"] [SIZE=3][SIZE=2][COLOR=#333333][FONT=open-sans]The researchers found that having higher baseline levels of vitamin D, insulin-like growth factor-1 (IGF-1) and its binding protein 3 (IGFBP3) was associated with a lower risk of worse frailty status four years later. "Vitamin D, besides maintaining bone health, regulates muscle function, and low vitamin D levels are linked to lower muscle mass and strength. IGF-1 affects muscle growth and repair, and its action and levels are modified by its carrier protein IGFBP3," Swiecicka said.[/FONT][/COLOR] [COLOR=#333333][FONT=open-sans]Also linked to a lower likelihood of frailty status worsening were higher baseline levels of the hormone dehydroepiandrosterone sulfate (DHEA-S), but only in the oldest men. Several potential pathways could link DHEA-S with frailty. Swiecicka said, "DHEA-S may have direct anabolic effect on muscle, and, more recently, its neuroprotective and immune system-modulating effects have been described."[/FONT][/COLOR][/SIZE] [/SIZE][COLOR=#000000][FONT='inherit'] [/FONT][/COLOR] [COLOR=#000000][FONT='inherit']http://www.endocrine.org/news-room/current-press-releases/higher-anabolic-hormone-levels-predict-lower-risk-of-worsening-frailty-in-men [/FONT][/COLOR] [COLOR=#000000][FONT='inherit'] [/FONT][/COLOR] [/QUOTE]
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Men with high levels of anabolic hormones less likely to develop worsening frailty
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